System and method for modulating the base rate during sleep for a rate-responsive cardiac pacemaker
Patent 5476483 Issued on December 19, 1995. Estimated Expiration Date: 
June 10, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 10, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMicroprocessor controlled rate-responsive pacemaker having automatic rate response threshold adjustment Self-adjusting rate-responsive pacemaker and method thereof Implantable device with circadian rhythm adjustment Patent #: 5143065 InventorsAssigneeApplicationNo. 258292 filed on 06/10/1994US Classes:607/17Parameter control in response to sensed physiological load on heartExaminersPrimary: Kamm, William E.Attorney, Agent or FirmInternational ClassA61N 001/365AbstractA system and method are provided for modulating the base rate of a transfer function for a rate-responsive cardiac pacemaker. Activity sensor measurements are used to derive activity variance measurements, which in turn are used to modulate the base pacing rate. In one embodiment, a histogram is used to store activity variance measurements collected over a period of about a week. The histogram is used to derive an activity variance threshold, which is compared to current activity variance measurements to determine if the patient is sleeping. If the patient is deemed to be sleeping, the pacing rate is set to a rate that comfortably meets the patient's low metabolic demands during sleep. In alternative embodiments, the activity variance measurements are applied to a base rate slope to modulate the base pacing rate.Other References
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