Solubility parameter based drug delivery system and method for altering drug saturation concentration
December 12, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3469308 Antiphlogistic analgesic adhesive Transdermal varapamil delivery device Microphase separated hydrogels for controlled release of bioactive materials Transdermal multipolymer drug delivery system Aminomethyl derivatives of biologically active substances, and enhanced delivery thereof across topical membranes Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration Transdermal estrogen/progestin dosage unit, system and process Diffusion matrix for transdermal drug administration and transdermal drug delivery devices including same Laminar structure for administering a chemical at a controlled release rate InventorsAssigneeApplicationNo. 722342 filed on 06/27/1991US Classes:424/448, Pressure sensitive adhesive means424/447, Bandages with incorporated medicaments424/449Transdermal or percutaneousExaminersPrimary: Denkat, JyothsnaAttorney, Agent or FirmForeign Patent References
International ClassA61F 013/02AbstractThe method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.Other References
Field of SearchPressure sensitive adhesive meansTransdermal or percutaneous Bandages with incorporated medicaments With solid polymer derived from at least one Si-H or Si-C reactant wherein at least one of the reactants forming the solid polymer is saturated; or with SPFI or SICP derived from a Si-H or Si-C reactant wherein at least one of the necessary reactants is saturated | |
