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US Patent 5474783 - Solubility parameter based drug delivery system and method for altering drug saturation concentration

US Patent Issued on December 12, 1995
Estimated Patent Expiration Date: Icon_subject December 12, 2012Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.

Other References

  • R. Lichtenberger et al., "Polymer Films From Aqueous Latex Dispersions As Carriers For Transdermal Delivery of Lipophilic Drugs", Proceed. Intern. Symp. Control. Rel Bioact. Mater., 15, (1988) pp. 147-150
  • K. L. Ulman et al., "Drug Permeability of Modified Silicone Polymers," Journal of Controlled Release, 10 (1989) pp. 273-281
  • Vaughn, Using Solubility Parameters in Cosmetics Formulation, 36 J. Soc. 319-333 (Sep./Oct. 1985)
  • Pfister & Hsieh, Permeation Enhancers Compatible With Transdermal Drug Delivery Systems Part I: Selection and Formulation Considerations, Medical Device Technology 48-56 (Sep./Oct. 1990)
  • Pfister & Hsieh, Permeation Enhancers Compatible With Transdermal Drug Delivery Systems Part II: System Design Considerations, Medical Device Technology 54-60 (Oct. 1990)
  • Sloan et al., Use of Solubility Parameters of Drug and Vehicle to Predict Flux Through Skin, 87 The Journal of Investigative Dermatology 244-252 (Aug. 1986

Inventors

Assignee

Application

No. 722342 filed on 06/27/1991

US Classes:

424/448, Pressure sensitive adhesive means424/447, Bandages with incorporated medicaments424/449Transdermal or percutaneous

Field of Search

424/448, Pressure sensitive adhesive means424/449, Transdermal or percutaneous424/447, Bandages with incorporated medicaments524/506With solid polymer derived from at least one Si-H or Si-C reactant wherein at least one of the reactants forming the solid polymer is saturated; or with SPFI or SICP derived from a Si-H or Si-C reactant wherein at least one of the necessary reactants is saturated

Examiners

Primary: Denkat, Jyothsna

Attorney, Agent or Firm

US Patent References

3469308, 4390520, Antiphlogistic analgesic adhesive
Issued on: 06/28/1983
Inventor: Nagai ,   et al.
4690683, Transdermal varapamil delivery device
Issued on: 09/01/1987
Inventor: Chien ,   et al.
4693887, Microphase separated hydrogels for controlled release of bioactive materials
Issued on: 09/15/1987
Inventor: Shah
4814168, Transdermal multipolymer drug delivery system
Issued on: 03/21/1989
Inventor: Sablotsky ,   et al.
4845081, Aminomethyl derivatives of biologically active substances, and enhanced delivery thereof across topical membranes
Issued on: 07/04/1989
Inventor: Sloan
4883669, Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration
Issued on: 11/28/1989
Inventor: Chien, et al.
4906169, Transdermal estrogen/progestin dosage unit, system and process
Issued on: 03/06/1990
Inventor: Chien, et al.
4911916, Diffusion matrix for transdermal drug administration and transdermal drug delivery devices including same
Issued on: 03/27/1990
Inventor: Cleary
4931281, Laminar structure for administering a chemical at a controlled release rate
Issued on: 06/05/1990
Inventor: Kim, et al.
4987893, Conformable bandage and coating material
Issued on: 01/29/1991
Inventor: Salamone, et al.
4994267, Transdermal acrylic multipolymer drug delivery system
Issued on: 02/19/1991
Inventor: Sablotsky
5149538, Misuse-resistive transdermal opioid dosage form
Issued on: 09/22/1992
Inventor: Granger, et al.
5151271, Pressure-sensitively adhering composite medicinal preparation
Issued on: 09/29/1992
Inventor: Otsuka, et al.
5154922Compositions for transdermal delivery of estradiol
Issued on: 10/13/1992
Inventor: Govil, et al.

Foreign Patent References

  • 0312265 EP. 04/21/1989
  • 0371496 EP. 11/21/1989
  • 2105990 GB. 04/21/1983
  • WO87/03477 WO. 06/21/1987

International Class

A61F 013/02

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