U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Detection of amplified or deleted chromosomal regions

Patent 5472842 Issued on December 5, 1995. Estimated Expiration Date: Icon_subject October 6, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Application

No. 132808 filed on 10/06/1993

US Classes:

435/6, Involving nucleic acid536/24.31Probes for detection of animal nucleotide sequences

Examiners

Primary: Fleisher, Mindy
Assistant: Ketter, James

Attorney, Agent or Firm

Foreign Patent References

  • 403402 EP 06/13/1991

International Classes

C12Q 001/68
C12N 015/11

Abstract

The present invention relates to in situ hybridization methods for the identification of new chromosomal abnormalities associated with various diseases. In particular, it provides probes which are specific to a region of amplification in chromosome 20.

Other References

  • Matthews et al, Anal. Biochem., v. 169, Feb. 1988, 1-25
  • Cremer et al, Hum. Genet., v. 80, 1988, 235-246
  • Lichter et al, Hum. Genet., v. 80, 1988, 224-234
  • Kallioniemi et al, Proc. Natl. Acad. Sci., v. 91, 1994, pp. 2156-2160
  • Kallioniemi et al, Science, v. 258, Oct. 30, 1992, 818-821
  • Wiegart et al, Nucleic Acids, Res, v. 19, 1991, 3237-3241
  • J. N. Lucas et al. "Translocations between two specific human chromosomes detected by three-color `chromosome painting`" Cytogenet Cell Genet vol. 62 pp. 11-12 (1993)
  • Annika Lindblom et al. "Deletions on Chromosome 16 in Primary Familial Breast Carcinomas Are Associated with Development of Distant Metastases" Cancer Research vol. 53, pp. 3707-3711, Aug. 15, 1993
  • Ulf S. R. Bergerheim et al. "Deletion Mapping of Chromosomes 8, 10, and 16 in Human Prostatic Carcinoma" Genes, Chromosomes & Cancer vol. 3, pp. 215-220 (1991)
  • Elisabeth Blennow et al. "Complete characterization of a large marker chromosome by reverse and forward chromosome painting" m Genet (1992) vol. 90, pp. 371-374. Received: 15 Jun. 1992/Revised: 6 Jul. 1992
  • Stefan Joos et al. "Detection of amplified DNA sequences by reverse chromosome painting using genomic tumor DNA as probe" m Genet (1993) vol. 90, pp. 584-589. Received: 30 Oct. 1992
  • Anne Kallioniemi et al. "Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors" Science vol. 258, Oct. 30, 1992 pp. 818-821
  • Peter Lichter et al. "High-Resolution Mapping of Human Chromosome 11 by in Situ Hybridization with Cosmid Clones" Science vol. 247 Jan. 5, 1990 pp. 64-69
  • Anne Kallioniemi et al. "ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization" Proc. Acad. Nat. Sci. 89:5321-5325 (1992)
  • Pinkel et al. "Fluorescence in situ hybridization with human chromosome-specific libraries: Detection of trisomy 21 and translocations of chromosome 4" Proc. Acad. Nat. Sci. 85:9138-9142 (1988)
  • Stokke, et al. "Genetic characterization of 20q amplication in human breast cancer" Abstract submitted to the 43rd Annual Meeting of the American Society of Human Genetics (Appendix 2
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
 
Sign InRegister
Username  
Password   
forgot password?