Method of preparing nanoparticle compositions containing charged phospholipids to reduce aggregation
May 10, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProcess for preparing lipoid-biologically active particles Novel drug delivery system for antiarrhythmics Drug delivery system Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs Surface modified drug nanoparticles Particulate vector useful in particular for the transport of molecules with biological activity and process for its preparation Lipsopheres for controlled delivery of substances Patent #: 5188837 InventorsApplicationNo. 240309 filed on 05/10/1994US Classes:424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/484, Matrices424/493, Containing polysaccharides (e.g., sugars)424/497Containing solid synthetic polymersExaminersPrimary: Kishore, Gollamudi S.Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/14AbstractThis invention discloses a composition comprised of nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface thereof and a charged phospholipid as a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. A preferred non-ionic surfactant surface modifier is a poloxamine or tyloxapol, and preferred charged phospholipid cloud point modifiers include dimyristoyl phosphatidyl glycerol. This invention further discloses a method of making nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface and a charged phospholipid as a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.Field of SearchLiposomesMatrices Particulate form (e.g., powders, granules, beads, microcapsules, and pellets) Cellulose derivatives Ethyl cellulose Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof Contains waxes, higher fatty acids, higher fatty alcohols Contains natural gums and resins Containing solid synthetic polymers Gelatin Containing proteins and derivatives Containing natural gums/resins Contains proteins or derivative or polysaccharides or derivative Coated (e.g., microcapsules) Containing polysaccharides (e.g., sugars) Contains solid synthetic resin LIPOSOMES (E.G., ENCAPSULATION, ETC.) Carboxylic acid, percarboxylic acid, or salt thereof (e.g., peracetic acid, etc.) Benzene ring nonionically bonded FORMATION OF SOLID PARTICULATE MATERIAL DIRECTLY FROM MOLTEN OR LIQUID MASS (E.G., LIQUID COMMINUTING) | |
