Patent References3652589 InventorsAssigneeApplicationNo. 268382 filed on 06/30/1994US Classes:514/282, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)514/646Benzene ring containingExaminersPrimary: Henley, III, RaymondAssistant: Jarvis, William R. A. Attorney, Agent or FirmInternational ClassesA61K 031/485A61K 031/135 AbstractThis invention relates to compositions comprising a tramadol material selected from the group consisting of tramadol, its stereoisomers and its pharmaceutically acceptable salts and either codeine or oxycodone, and their use in treating pain. When the components, i.e., tramadol materials and either of codeine or oxycodone, of the composition are within certain ratios of pharmacological effects of the compositions are superaddditive (synergistic). | |