Chemiluminescent acridinium salts
Patent 5468646 Issued on November 21, 1995. Estimated Expiration Date: 
January 3, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 3, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3431264 Aqueous chemiluminescent systems Phenanthridinium ester as a labelling compound in luminometric immunoassay Polysubstituted aryl acridinium esters Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom Hydrolytically stable chemiluminescent labels and their conjugates, and assays therefrom by adduct formation Patent #: 5338847 InventorsApplicationNo. 368258 filed on 01/03/1995US Classes:436/501, BIOSPECIFIC LIGAND BINDING ASSAY435/6, Involving nucleic acid435/7.1, Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay435/968, HIGH ENERGY SUBSTRATES (E.G., FLUORESCENT, CHEMILUMINESCENT, RADIOACTIVE, ETC.)436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/536, INVOLVING IMMUNE COMPLEX FORMED IN LIQUID PHASE436/544, Producing labeled antigens436/546, Fluorescent label436/548, Monoclonal antibody436/800, FLUORESCENT DYES (E.G., RHODAMINE, ETC.)436/805, OPTICAL PROPERTY530/389.8, Binds drug, hapten, hapten-carrier complex, or specifically-identified chemical structure (e.g., theophylline, digoxin, etc.)546/104Nitrogen, other than as nitro or nitroso, attached directly or indirectly to the acridine ring system by nonionic bondingExaminersPrimary: Spiegel, Carol A.Attorney, Agent or FirmForeign Patent References
International ClassG01N 031/00AbstractAcridinium sulfonylamides and isomers, such as phenanthridinium sulfonylamides, may be employed in applications including chemiluminmescent immunoassays. Methods for synthesis of these compounds include contacting an amine with a sulfonylhalide to form a sulfonamide and acylating with an activated carboxylic acid of an acridine or isomer thereof. The N-sulfonyl-9-acridinium carboxamide and isomers may be conjugated to antigens, haptens, antibodies, and nucleic acids for use in chemiluminescent assays.Other References
Field of SearchInvolving nucleic acidInvolving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay HIGH ENERGY SUBSTRATES (E.G., FLUORESCENT, CHEMILUMINESCENT, RADIOACTIVE, ETC.) BIOSPECIFIC LIGAND BINDING ASSAY INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS INVOLVING IMMUNE COMPLEX FORMED IN LIQUID PHASE Producing labeled antigens Fluorescent label Monoclonal antibody FLUORESCENT DYES (E.G., RHODAMINE, ETC.) OPTICAL PROPERTY Binds drug, hapten, hapten-carrier complex, or specifically-identified chemical structure (e.g., theophylline, digoxin, etc.) N-glycosides wherein the N is part of an N-hetero ring which hetero ring is part of a polycyclo ring system containing an N-hetero ring and an additional hetero ring (e.g., rebeccamycin, etc.) Nitrogen, other than as nitro or nitroso, attached directly or indirectly to the acridine ring system by nonionic bonding |
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