Nitroxides as protectors against oxidative stress
Patent 5462946 Issued on October 31, 1995. Estimated Expiration Date: 
October 31, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
October 31, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsAssigneeApplicationNo. 859622 filed on 03/20/1992US Classes:514/315, Piperidines514/256, 1,3-diazines (e.g., pyrimidines, etc.)514/263.2, Additional hetero ring attached directly or indirectly to the purine ring system by nonionic bonding514/352, Nitrogen attached directly to the six-membered hetero ring by nonionic bonding514/370, Nitrogen bonded directly to ring carbon of the thiazole ring514/377, Nitrogen bonded directly to ring carbon of the oxazole ring514/398, Chalcogen or nitrogen bonded directly to the imidazole ring by nonionic bonding514/406, Pyrazoles514/426, Nitrogen bonded directly to the five-membered hetero ring by nonionic bonding514/427Two double bonds between ring members of the five-membered hetero ring (e.g., pyrrole, etc.)ExaminersPrimary: Henley, III, RaymondAssistant: Jarvis, William R. A. Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/445A61K 031/505 A61K 031/52 A61K 031/44 A61K 031/425 A61K 031/415 A61K 031/40 AbstractThe instant invention is directed to the use of a biologically compatible composition, containing an effective amount of a metal independent nitroxide compound which is preferably represented by the formula ##STR1## wherein R1 is --CH3 ; R2 is --C2 H5, --C3 H7, --C4 H9, --C5 H11, --C6 H13, --CH2 --CH(CH3)2, --CHCH3 C2 H5, or --(CH2)7 --CH3, or wherein R1 and R2 together form spirocyclopentane, spirocyclohexane, spirocycloheptane, spirocyclooctane, 5-cholestane, or norbornane, R3 is --O. or --OH, or a physiologically acceptable salt thereof, and a pharmaceutically acceptable carrier, as antioxidants capable of protecting cells, tissues, organs, and whole organisms against the deleterious effects of harmful oxygen-derived species generated during oxidative stress.Other References
Field of SearchPiperidinesTwo double bonds between ring members of the five-membered hetero ring (e.g., pyrrole, etc.) Chalcogen or nitrogen bonded directly to the imidazole ring by nonionic bonding Nitrogen bonded directly to ring carbon of the oxazole ring Nitrogen bonded directly to ring carbon of the thiazole ring Pyrazoles Nitrogen bonded directly to the five-membered hetero ring by nonionic bonding Nitrogen attached directly to the six-membered hetero ring by nonionic bonding 1,3-diazines (e.g., pyrimidines, etc.) | |
