Process for preparing pyrrolidinylacetamide derivatives
Patent 5461157 Issued on October 24, 1995. Estimated Expiration Date: December 15, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
A process for preparing a 2-(1-pyrrolidinyl)acetamide derivative useful as a cerebral function improving agent is disclosed, comprising reacting a halogenoacetamide derivative with substituted or unsubstituted 2-pyrrolidinone, the halogenoacetamide derivative being prepared by reacting an amine and a halogenoacetyl chloride. High yields of the intermediate compound as well as the final product are attained at low cost.
Other References
Daskalov, Kh.; Georgiev, A.; Konstantinova, K.; (Bulgaria), Tr. Nauchnoizsled Khim.-Farm Inst., (1985). 15. p. 21-32 (and Abstract translated)
Yakugaku Zasshi (Pharmacological Journal), vol. 99(2), pp. 146-254 (1979