U.S. patents available from 1976 to present.
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Methods for providing testosterone and optionally estrogen replacement therapy to women

Patent 5460820 Issued on October 24, 1995. Estimated Expiration Date: Icon_subject August 3, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Transdermal estrogen/progestin dosage unit, system and process
Patent #: 5023084
Issued on: 06/11/1991
Inventor: Chien, et al.

Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels Patent #: 5152997
Issued on: 10/06/1992
Inventor: Ebert, et al.

Inventors

Application

No. 099923 filed on 08/03/1993

US Classes:

424/449, Transdermal or percutaneous424/448Pressure sensitive adhesive means

Examiners

Primary: Phelan, D. Gabrielle

Attorney, Agent or Firm

International Class

A61F 013/00

Abstract

A method of providing testosterone replacement therapy to a woman in need of such therapy comprising applying a testosterone-delivering patch to the skin of said woman which patch transdermally delivers 50 to 500 μg/day of testosterone to the woman.

Other References

  • Urman et al., "Elevated serum testosterone, hirsutism, and virilism associated with combined and androgen-estrogen hormone replacement therapy" Obstetrics & Gynecology (1991) 77:595-598
  • Sherwin, B. B., et al., "Sex steroids and affect in the surgical menopause: A double blind, cross-over study" Psychoneuroendocrinology (1985) 10(3):325ࣙ335
  • Sherwin, B. B., et al., "Androgen enhances sexual motivation in females: A prospective, crossover study of sex steroid administration in the surgical menopause" Psychosomatic Medicine (1985) 47(4):339-351
  • Sherwin, B. B., et al., "Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause" American Journal of Obstetrics and Gynecology (1985) 151(2):153-160
  • Yu, J-W., et al., "Transdermal dual controlled delivery of testosterone and estradiol: (I) Impact of system design" Drug Develoment and Industrial Pharmacy (1991) 17(14):1883-1904
  • Yu, J-W., et al., "Transdermal dual controlled delivery of testosterone and estradiol: (II) Enhanced skin permeability and membrane-moderated delivery" Drug Development and Industrial Pharmacy (1991) 17(14):1905-193
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