Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
February 25, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesNon-immunogenic polypeptides Peptide macromolecular complexes Induction of immunological tolerance Drug delivery by polymeric carriers Bifunctional linker Anhydrous enhanced coupling of proteins Biodegradable polymeric drug delivery system with adjuvant activity Biodegradable synthesis polypeptide and its therapeutic use Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, their use as immunotoxin potentiators and the intermediate activated ionophores Heterogeneous interpenetrating polymer networks for the controlled release of drugs InventorsAssigneeApplicationNo. 023069 filed on 02/25/1993US Classes:424/78.17, Aftertreated polymer (e.g., grafting, blocking, etc.)424/78.08SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)ExaminersPrimary: Webman, Edward J.Assistant: Kulkosky, Peter F. Attorney, Agent or FirmInternational ClassesA61K 031/74A61K 031/765 A61K 031/785 AbstractCopolymers of poly(alkylene oxides) and amino acids or peptide sequences are disclosed, which amino acids or peptide sequences have pendant functional groups that are capable of being conjugated with pharmaceutically active compounds for drug delivery systems and cross-linked to form polymer matrices functional as hydrogel membranes. The copolymers can also be formed into conductive materials. Methods are also disclosed for preparing the polymers and forming the drug conjugates, hydrogel membranes and conductive materials.Other References
| |
