Calibrated spectrographic imaging
September 26, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References Re31815 Flying spot fluoro-meter for oxidized flavoprotein and reduced pyridine nucleotide Method and system for non-invasive detection of zinc protoporphyrin in erythrocytes Method and apparatus for in-vivo spectroscopic analysis Method of screening for sickle cell disease by detection of porphyrins and porphyrin metabolites in human dentition Human and animal tissue photoradiation system and method Cancer diagnosis device utilizing laser beam pulses Method and apparatus for measuring natural retinal fluorescence Arrangement for measuring diffusing particles Probe-and-fire lasers InventorsApplicationNo. 920135 filed on 07/24/1992US Classes:600/342, Light conducting fiber inserted in body250/339.01, With selection of plural discrete wavelengths or bands250/340, Methods356/318, Monochromatic (e.g., laser)356/326, Utilizing a spectrometer600/317By fluorescent emissionExaminersPrimary: Smith, Ruth S.Attorney, Agent or FirmForeign Patent References
International ClassA61B 006/00AbstractThe present application is directed to the use of photon migration analysis to provide a method of analyzing the diffuse reflectance, fluorescence, Raman or other types of spectra obtained from tissue. This procedure provides a means for processing spectral data such that the distortion in fluorescence spectra, for example, caused by the interplay of a variety of factors such as scattering, absorption, geometry and boundary conditions, can be precisely removed simply by measuring the diffuse reflectance spectrum as well as a second selected spectrum, such as fluorescence, and adjust the spectrum with the reflectance spectrum as described herein. By this procedure, the sample-to-sample variability is minimized. The intrinsic spectrum extracted by this procedure can be easily deconvoluted and provide quantitative information about the physicochemical composition of tissue. Analytical procedures for clinical diagnosis have been developed based on this method.Other References
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