U.S. patents available from 1976 to present.
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Pulmonary drug delivery system

Patent 5451569 Issued on September 19, 1995. Estimated Expiration Date: Icon_subject April 19, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method and apparatus for administering dehydrated liposomes by inhalation
Patent #: 4895719
Issued on: 01/23/1990
Inventor: Radhakrishnan, et al.

Methods and compositions for the treatment of lung conditions
Patent #: 4944941
Issued on: 07/31/1990
Inventor: Ammann

Pulmonary administration of pharmaceutically active substances
Patent #: 5006343
Issued on: 04/09/1991
Inventor: Benson, et al.

Method for administering pharmaceuticals, including liquid surfactant, to the lungs
Patent #: 5207220
Issued on: 05/04/1993
Inventor: Long

Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations
Patent #: 5230884
Issued on: 07/27/1993
Inventor: Evans, et al.

Methods and apparatus for drug delivery using supercritical solutions Patent #: 5301664
Issued on: 04/12/1994
Inventor: Sievers, et al.

Inventors

Assignee

Application

No. 229600 filed on 04/19/1994

US Classes:

514/3, Insulin or derivative514/807, OXYTOXIN, VASOPRESSIN OR DERIVATIVES514/975CHARACTERIZED BY THE DESIGNATED SURFACTANT USED

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

International Classes

A61K 038/28
A61K 038/11
A61K 045/08

Abstract

The present invention provides a method of improving the efficiency of absorption into the bloodstream of drugs delivered through the pulmonary route. The drug is mixed with surfactant, preferably a surfactant naturally produced by the lung. This method is found to enhance the absorption of pharmaceutical compositions, and in particular those comprising protein, eg insulin, or peptides, eg vasopressin.

Other References

  • Yamamoto et al., CA. 120:226732Y of J. Pharm. Pharmacol., 46(1):14-18 (19.
  • Yoshida et al., CA. 116:262569B of JP 90-149545 (Jun. 7, 1990)
  • Okumura et al., Embase Abstract of Int. J. Pharm., 88/1-3, (63-73), 1992
  • Sanchez et al., Medline Abstract of Eur. J. Drug Metab. Pharmakotasot, No. 3 120-4 (1991)
  • Baglioni et al., Medline Abstract of J. Interferon. Res., 10(5):497-504, Oct. 1990
  • Stoltz, CA. 108:137901 of EP. 242643 (Oct. 28, 1987)
  • Salzmon et al., Medline Abstract of N. Engl. J. Med., 312(17):1078-1084 Apr. 25, 1984
  • Hirai et al., CA. 86:145958d of Ger. Offen. DE 2620446 (Mar. 3, 1977
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