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Pain management with liposome-encapsulated analgesic drugs

Patent 5451408 Issued on September 19, 1995. Estimated Expiration Date: Icon_subject March 23, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
Patent #: 4485054
Issued on: 11/27/1984
Inventor: Mezei ,   et al.

Multiphase liposomal drug delivery system
Patent #: 4761288
Issued on: 08/02/1988
Inventor: Mezei

Liposomal local anesthetic and analgesic products Patent #: 4937078
Issued on: 06/26/1990
Inventor: Mezei, et al.

Inventors

Assignee

Application

No. 216590 filed on 03/23/1994

US Classes:

424/450, Liposomes424/1.13, In aerosol, fine spray, effervescent, pressurized fluid, vapor or gas, or complete composition therefor424/1.21, Molecular bilayer structure (e.g., vesicle, liposome)514/817ANESTHETIC, TOPICAL

Examiners

Primary: Raymond, Richard L.

Attorney, Agent or Firm

International Class

A61K 009/50

Abstract

Liposome-encapsulated opioid analgesic agents delivered by the pulmonary route provide local, or systemic analgesia superior to that produced by the solution form of these agents administered by parentral (intravenous, intramuscular, or subcutaneous injection) or oral routes.

Other References

  • Bangham et al., J. Mol. Biol., 13:238-252, 1965
  • Mezei, Controlled Release Dosage Forms, Tipnis (ed), Bombay College of Pharmacy, India, pp. 37-46, 1988
  • Meisner et al., Proceedings, 15th Int'l Symposium on Controlled Release of Bioactive Materials, 15:262-263, 1988
  • Mezei et al., Drug Permeation Enhancement, Theory and Application, Hsieh (ed), Marcel Dekker Inc., New York, 1993, pp. 171-198
  • Gesztes et al., Anesth. Analg. 67:1079-1081, 1988
  • Bernards et al. Anesthesiology, 77:529-535, 1992
  • Ready, Anesthesia, 3rd ed., Miller (ed), Churchill Livingston, New York, 1990, pp. 2135-2146
  • Khojasteh et al., J. Clin. Oncology 5:956-961, 1987
  • Varvel et al., Anesthesiology 70:928-934, 1989
  • Worsley et al., Anaesthesia 45:449-451, 1990
  • Higgins et al., Anaesthesia 46:973-976, 1991
  • Mihalko et al., Liposomes as Drug Carriers, Gregoriadis (ed), John Wiley & Sons Ltd., Toronto, 1988, pp. 679-694
  • Meisner et al., J. Microencapsulation 6:379-387, 1989
  • Meisner, Pharmaceutical Particulate Carriers: Therapeutic Application, Roland (ed), Marcel Dekker Inc., New York 1993, pp. 31-63
  • Oyarzun et al., An. Rev. Resp. Dis., 121:709-721, 1980
  • Myers et al., An. Rev. Resp. Dis., 141A675, 1990
  • Ivey et al., Pediatr. Res., 11:573, 1977
  • Morley et al., Lancet, i:64-68, 1981
  • Thomas et al., Chest, 99:1268-1270, 199
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