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US Patent 5451408 - Pain management with liposome-encapsulated analgesic drugs

US Patent Issued on September 19, 1995
Estimated Patent Expiration Date: Icon_subject March 23, 2014Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

Liposome-encapsulated opioid analgesic agents delivered by the pulmonary route provide local, or systemic analgesia superior to that produced by the solution form of these agents administered by parentral (intravenous, intramuscular, or subcutaneous injection) or oral routes.

Other References

  • Bangham et al., J. Mol. Biol., 13:238-252, 1965
  • Mezei, Controlled Release Dosage Forms, Tipnis (ed), Bombay College of Pharmacy, India, pp. 37-46, 1988
  • Meisner et al., Proceedings, 15th Int'l Symposium on Controlled Release of Bioactive Materials, 15:262-263, 1988
  • Mezei et al., Drug Permeation Enhancement, Theory and Application, Hsieh (ed), Marcel Dekker Inc., New York, 1993, pp. 171-198
  • Gesztes et al., Anesth. Analg. 67:1079-1081, 1988
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  • Worsley et al., Anaesthesia 45:449-451, 1990
  • Higgins et al., Anaesthesia 46:973-976, 1991
  • Mihalko et al., Liposomes as Drug Carriers, Gregoriadis (ed), John Wiley & Sons Ltd., Toronto, 1988, pp. 679-694
  • Meisner et al., J. Microencapsulation 6:379-387, 1989
  • Meisner, Pharmaceutical Particulate Carriers: Therapeutic Application, Roland (ed), Marcel Dekker Inc., New York 1993, pp. 31-63
  • Oyarzun et al., An. Rev. Resp. Dis., 121:709-721, 1980
  • Myers et al., An. Rev. Resp. Dis., 141A675, 1990
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Inventors

Assignee

Application

No. 216590 filed on 03/23/1994

US Classes:

424/450, Liposomes424/1.13, In aerosol, fine spray, effervescent, pressurized fluid, vapor or gas, or complete composition therefor424/1.21, Molecular bilayer structure (e.g., vesicle, liposome)514/817ANESTHETIC, TOPICAL

Field of Search

424/1.13, In aerosol, fine spray, effervescent, pressurized fluid, vapor or gas, or complete composition therefor424/1.21, Molecular bilayer structure (e.g., vesicle, liposome)424/450, Liposomes514/817ANESTHETIC, TOPICAL

Examiners

Primary: Raymond, Richard L.

Attorney, Agent or Firm

US Patent References

4485054, Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
Issued on: 11/27/1984
Inventor: Mezei ,   et al.4761288, Multiphase liposomal drug delivery system
Issued on: 08/02/1988
Inventor: Mezei4937078Liposomal local anesthetic and analgesic products
Issued on: 06/26/1990
Inventor: Mezei, et al.

International Class

A61K 009/50

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