Amplification of the VB12 uptake system using polymers
Patent 5449720 Issued on September 12, 1995. Estimated Expiration Date: 
May 24, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 24, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesPreparation of ligand-polymer conjugate having a controlled number of introduced ligands Oral compositions of proteinaceous medicaments Vectored drug delivery system using a cephaloplastin linking agent and a methed of using the system Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light Dehydrated collagen-polymer strings Patent #: 5308889 InventorsAssigneeApplicationNo. 064892 filed on 05/24/1993US Classes:525/54.1, Containing chemically combined protein or biologically active polypeptide424/484, Matrices424/485, Natural gums, resin or latex424/486, Synthetic polymer424/487, Acrylic acid and derivatives424/488, Polysaccharides (e.g., cellulose, etc.)514/656, Polycyclo ring system530/812, Peptides or proteins is immobilized on, or in, an organic carrier530/815, Carrier is a synthetic polymer530/816Attached to the carrier via a bridging agentExaminersPrimary: Nutter, Nathan M.Attorney, Agent or FirmForeign Patent References
International ClassesC08F 283/00C08G 063/91 A01N 033/02 AbstractThe invention relates to the oral delivery of peptide and protein pharmaceuticals using the vitamin B12 (VB12) uptake system, with the delivery being amplified using polymers. More particularly, the invention concerns a complex having the general formula:(V--Q)n --P--(Q'--A)mwhere, V is a carrier which will bind to natural intrinsic factor (IF) selected from vitamin B12 or an analogue thereof, n is the molar substitution ratio of V in the complex, and is a number from 1.0 to about 10, P is a pharmaceutically acceptable polymer, A is a pharmaceutically active substance, m is the molar substitution ratio of A in the complex, and is a number greater than 1.0 to about 1000, Q and Q' are independently a covalent bond, or a spacer compound linking V, P and A by covalent bonds.Other References
Field of SearchContaining chemically combined protein or biologically active polypeptidePeptides or proteins is immobilized on, or in, an inorganic carrier Peptides or proteins is immobilized on, or in, an organic carrier Carrier is a synthetic polymer Attached to the carrier via a bridging agent Matrices Natural gums, resin or latex Synthetic polymer Acrylic acid and derivatives Polysaccharides (e.g., cellulose, etc.) Polycyclo ring system |
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