Patent 5447841 Issued on September 5, 1995. Estimated Expiration Date: September 5, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
435/6, Involving nucleic acid435/243, MICRO-ORGANISM, PER SE (E.G., PROTOZOA, ETC.); COMPOSITIONS THEREOF; PROCES OF PROPAGATING, MAINTAINING OR PRESERVING MICRO-ORGANISMS OR COMPOSITIONS THEREOF; PROCESS OF PREPARING OR ISOLATING A COMPOSITION CONTAINING A MICRO-ORGANISM; CULTURE MEDIA THEREFOR435/805, TEST PAPERS435/820, SUBCELLULAR PARTS OF MICRO-ORGANISMS436/63, BIOLOGICAL CELLULAR MATERIAL TESTED436/64, CANCER436/501, BIOSPECIFIC LIGAND BINDING ASSAY536/22.1, N-glycosides, polymers thereof, metal derivatives (e.g., nucleic acids, oligonucleotides, etc.)536/23.1, DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)536/24.3, Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNA536/24.31, Probes for detection of animal nucleotide sequences536/24.32, Probes for detection of microbial nucleotide sequences536/25.42Denaturant utilized
Methods and compositions for chromosome-specific staining are provided. Compositions comprise heterogenous mixtures of labeled nucleic acid fragments having substantially complementary base sequences to unique sequence regions of the chromosomal DNA for which their associated staining reagent is specific. Methods include methods for making the chromosome-specific staining compositions of the invention, and methods for applying the staining compositions to chromosomes.
Other References
Pinkel et al. (1986) Proceedings of the Nat'l Acad Sci (USA) vol. 83, pp. 2934-2938
Ardeshir et al. (1983) Mol. & Cell. Biology, vol. 3, No. 11, pp. 2076-2088
Fisher et al. (1984) Proceedings of the Nat'l Acad Sci (USA) vol. 81, pp. 520-524
Weiss et al. (1984) Nature, vol. 310, pp. 650-655
Litt et al. (1985) Proceedings of the Nat'l Acad Sci (USA) vol. 82, pp. 6206-6210
Yunis et al. (1977) Chromosoma, vol. 61, pp. 335-344
Langer-Safer et al. (1982) Proc. Nat'l Acad Sci (USA) vol. 79, pp. 4381-4385
Montgomery et al. (1983) Proc. Natl Acad Sci (USA) vol. 80, pp. 5724-5728
Lewin, B. (editor), Genes (2nd Edition John Wiley & Sons, Inc. 1984) pp. 298-294 and pp. 464-465
Gray et al., (Abstract) "Flow Cytometric Detection of Chromosome Aberrations"; Conference on Flow Cytometry in Cell Biology and Genetics, Jan. 15-17, 1985 (San Francisco, Calif.)
Szabo and Ward, TIBS, 7(11): 425-427 (Dec. 1982)
Gall and Pardue, PNAS (USA), 63: 378-383 (1969)
Buongiorno-Nardelli and Amaldi, Nature, 225: 946-948 (1970)
John et al. Nature, 223: 582-587 (1969)
Schardin et al., Hum. Genet., 71: 281-287 (1985)
Durnam et al., Som. Cell Molec. Genetics, 11(6): 571-577 (1985)
Manuelidis, Hum. Genet., 71: 288-293 (1985)
Herzenberg et al., PNAS (USA), 76 (3): 1453-1455 (Mar. 1979)
Britten et al., Methods of Enzymology, 29: 363-418 (1974)
Benton and Davis, Science, 196: 180-182 (1977)
Landegent et al., Nature, 317: 175-177 (12 Sep. 1985)
Olsen et al., Biochemistry, 19: 2419-2428 (1980)
Schmeckpeper et al., Proc. Natl. Acad. Sci. USA 76(12): 6525-6528 (1979)
Brison et al., Molecular and Cellular Biology, 2 (15): 578-587 (1982)
Manuelidis and Ward, Chromosoma (Berl.) 91: 28-38 (1984)
Lawrence Livermore National Laboratory publication, Energy and Technology Review, Jul. 1985, pp. 82-83 entitled "Chromosome--Specific Human Gene Libraries"
Van Dilla and Deaven (Abstract), Am J. of Human Genetics, 37 (R Supplement) (Jul. 1985)
Lewin, R., Science, 221 (4616): 1167 (16 Sep. 1983)
Albertson, EMBO J., 4 (10): 2493-2498 (1985)
Albertson, EMBO J., 3 (6): 1227-1234 (1984)
Cox et al., Developmental Biology, 101: 485-502 (1984)
Sealy et al. Nucleic Acid Research, 13: 1905-1922 (1985)
Harper and Saunders, Chromosoma (Berl) 83: 431-439 (1981)
Wallace et al., Nucleic Acids Research, 9 (4): 879-894 (1981)
Scalenghe et al., Chromosoma (Berl.), 82: 205-216 (1981)
Jabs et al., PNAS (USA), 81: 4884-4888 (1984)
Stewart et al., Nucleic Acids Research, 13(11): 4125-4132 (1985)
Landegent et al., Exp. Cell Res., 153: 61-72 (1984)
Cannizzaro et al., Cytogenet. Cell Genet. 39: 173-178 (1985)
Kao et al., Human Genetics, 62: 337-341 (1982)
Harper and Saunders, PNAS, 78: 4458-4460 (1981)
Willard et al., Nucleic Acids Res., 11: 2017-2033 (1983)
Manuelids, PNAS (USA), 81: 3123 (1984)
Rappold et al., Human Genetics, 67: 317 (1984)
Cantor and Schimmel, Biophysical Chemistry: The Behavior of Biological Macromoles (Part III, p. 1228) (Freeman 1980)
Thompson et al, Thompson & Thompson: Genetics in Medicine, 5th ed., W. B. Saunders Co., Philadelphia, Pa., pp. 38-39 (1991)
Leroy E. Hood et al, Molecular Biology of Eucaryotic Cells, W. A. Benjamin, Inc., Menlo Park, Calif., pp. 47-51 (1975)
J. E. Landegent, et al, "Use of Whole Cosmid Cloned Genomic Sequences for Chromosomal Localization by Non-Radioactive In Situ Hybridization," Human Genetics, 77:366-370 (1987)
"Detection of DNA Sequences in Nuclei in Suspension by In Situ Hybridization and Dual Beam Flow Cytometry" (UCRL 93372 Abstract) Trask, B., et al--Analytical Cytology X Conference, Hilton Head Resort, Hilton Head Island, S.C., Nov. 17, 1985-Nov. 22, 1985
"Cytogenetics Using Fluorescent Nucleic Acid Probes and Quantitative Microscopic Measurement" (UCRL 93269 Abstract) Pinkel, D., et al--Analytical Cytology X Conference, Hilton Head Resort, Hilton Head Island, S.C., Nov. 17, 1985-Nov. 22, 1985
"Rapid Quantitative Cytogenic Analysis Using Fluorescently Labeled Nucleic Acid Probes", (UCRL 93553 Abstract), Pinkel, D., et al, U.S.-Japan Joint Environmental Panel Conf., Research Triangle Park, N.C., Oct. 21, 1985-Oct. 23, 1985
"Chromosome Translocation of Low Radiation Doses Quantified Using Fluorescent DNA Probes", (UCRL 93837 Abstract), Straume, T., et al, Radiation Research Society Meeting, Las Vegas, Nevada, Apr. 12, 1986-Apr. 17, 1986
"Rapid Translocation Analysis Using Fluorescence In Situ Hybridization: Applied to Long Term Biological Dosimetry", (UCRL 102265 Abstract), Lucas, J. N., et al, Radiation Research Meeting, New Orleans, Louisiana, Apr. 7, 1990-Apr. 12, 1990
"Detection of Structural and Numerical Abnormalities in Metaphase Spreads and Interphase Nuclei Using In Situ Hybridization", Pinkel, D., et al, Cancer Genet. and Cytogenet. (UCRL 101043 Abstract) 41:236 (Oct. 1989)
"Flow Cytometric Detection of Chromosome Aberrations," (Abstract) Gray et al, Conference on Flow Cytometry in Cell Biology and Genetics, Clift Hotel, San Francisco, California, Jan. 15, 1985-Jan. 17, 1985
"Simplified Cytogenetics Using Biotin Labeled Nucleic Acid Probes and Quantitative Fluorescence Microscopy," (UCRL 93243 Abstract), Pinkel et al, American Journal of Human Genetics (Supplement), 37:A112, Jul. 1985
"Detection of Translocations and Aneuploidy in Metaphase Spreads and Interphase Nuclei by In Situ Hybridization with Probes Which Stain Entire Human Chromosomes," (UCRL 101042 Abstract) Pinkel et al, 21st Oak Ridge Conference on Advanced Conepts in the Clinical Laboratory, Apr. 13, 1989-Apr. 14, 1989
"Colony Hybridization: A Method for the Isolation of Cloned DNAs That Contain A Specific Gene," Grunstein et al, PNAS, USA, vol. 72, No. 10, Oct. 1975, pp. 3961-3965
"Heterogeneity of Chromosome 22 Breakpoint in Philadelphia-positive (Ph+) Acute Lymphocytic Leukemia," Erikson et al, PNAS, USA, vol. 83, Mar. 1986, pp. 1807-1811
Cremer et al, "Rapid Metaphase and Interphase Detection of Radiation-Induced Chromosome Aberrations in Human Lymphocytes by Chromosomal Suppression In Situ Hybridization," Cytometry, vol. 11, 1990, pp. 110-118
Bookstein et al, "Human Retinoblastoma Susceptibility Gene: Genomic Organization and Analysis of Heterozygous Intragenic Deletion Mutants," PNAS (USA), vol. 85, Apr. 1988, pp. 2210-2214
Cohen et al, "Hereditary Renal-Cell Carcinoma Associated with a Chromosomal Translocation," N. Engl. J. Med., vol. 301, No. 11, Sep. 1979, pp. 592-595
Trask et al, "The Proximity of DNA Sequences in Interphase Cell Nuclei Is Correlated to Genomic Distance and Permits Ordering of Cosmids Spanning 250 Kilobase Pairs," Genomics, vol. 5, 1989, pp. 710-717
McCormick, "The Polymerase Chain Reaction and Cancer Diagnosis," Cancer Cells, vol. 1, No. 2, Oct. 1989, pp. 56-61
Lawrence et al, "Sensitive, High-Resolution Chromatin and Chromosome Mapping In Situ: Presence and Orientation of Two Closely Integrated Copies of EBV in a Lymphoma Line," Cell, vol. 52, Jan. 1988, pp. 51-61
Cremer et al, "Detection of Chromosome Aberrations in Metaphase and Interphase Tumor Cells by in situ Hybridization Using Chromosome-Specific Library Probes," Human Genetics, vol. 80, 1988, pp. 235-246
Pinkel et al, "Detection of Structural Chromosome Aberrations in Metaphase Spreads and Interphase Nuclei by in situ Hybridization High Complexity Probes Which Stain Entire Human Chromosomes," Am. J. Hum. Genet. (Supplement) vol. 43, No. 3, Sep. 1988, p. A118 (Abstract 0471:11.5)
Lichter et al, "Delineation of Individual Human Chromosomes in Metaphase and Interphase Cells by in situ Suppression Hybridization Using Recombinant DNA Libraries," Human Genet., vol. 80, 1988, pp. 224-234
Collins and Weissman, "Directional cloning of DNA fragments at a large distance from an initial probe: A circularization method", PNAS (USA), 81: 6812-6816 (Nov. 1984)
LeGrys et al, "Clinical Applications of DNA Probes in the Diagnosis of Genetic Diseases," CRC Crit. Rev. Clin. Lab. Sci., vol. 25, No. 4, 1987, pp. 255-274
Lichter et al, "Rapid Detection of Human Chromosome 21 Aberrations by in situ Hybridization," PNAS USA, vol. 85, Dec. 1988, pp. 9664-9668
Pinkel et al, "Cytogenetic Analysis by In Situ Hybridization with Fluorescently Labeled Nucleic Acid Probes," Cold Spring Harbor Symposia on Quantitative Biology, vol. Ll, 1986, pp. 151-157
Pinkel et al, "Genetic Analysis by Quantitative Microscopy and Flow Cytometry Using Fluorescence In Situ Hybridization with Chromosome-Specific Nucleic Acid Probes," Am. J. Hum. Genet. (Supplement), vol. 39, No. 3, Sep. 1986, p. A129 (379)
Pinkel et al, "Cytogenetic Analysis During Leukemia Therapy Using Fluorescence in situ Hybridization with Chromosome-Specific Nucleic Acid Probes," Am. J. Hum. Genet. (Supplement), vol. 41, No. 3, Sep. 1987, p. A34 (096; 12.12)
Pinkel et al, "Simplified Cytogenetics Using Biotin Labeled Nucleic Acid Probes and Quantitative Fluorescence Microscopy," Am. J. Hum. Genet. (Supplement), vol. 37, No. 4, Jul. 1985, pp. A112 (328;17.2)
Cremer et al, "Detection of Chromosome Aberrations in the Human Interphase Nucleus by Visualization of Specific Target DNAs with Radioactive and Non-Radioactive in situ Hybridization Techniques: Diagnosis of Trisomy 18 with Probe L1.84," Hum. Genet., vol. 74, 1986, pp. 346-352
Selypes et al, "A Noninvasive Method for Determination of the Sex and the Karyotype of the Fetus from the Material Blood," Hum. Genet. vol. 79, 1988, pp. 357-359
Fuscoe et al, "An Efficient Method for Selecting Unique-Sequence Clones from DNA Libraries and Its Application To Fluorescent Staining of Human Chromosome 21 Using in Situ Hybridization," Genomics, vol. 5, 1989, pp. 100-109
Devilee et al, "Detection of Chromosome Aneuploidy in Interphase Nuclei from Human Primary Breast Tumors Using Chromosome-specific Repetitive DNA Probes," Cancer Res., vol. 48, Oct. 1988, pp. 5825-5830
Friend et al, "A Human DNA Segment with Properties of the Gene that Predisposes to Retinoblastoma and Osteosarcoma," Nature, vol. 323, Oct. 16, 1986, pp. 643-646
Nederlof et al, "Detection of Chromosome Aberrations in Interphase Tumor Nuclei by Nonradioactive In Situ Hybridations," Cancer Genet. Cytogenet., vol. 42, 1989, pp. 87-98
Sparkes et al, "Regional Assignment of Genes for Human Esterase D and Retinoblastoma in Chromosome Band 13q14," Science, vol. 208, May 30, 1988, pp. 1042-1044
Trent et al, "Report of the Committee on Structural Chromosome Changes in Neoplasia," Cytogenet. Cell Genet., vol. 51, 1989, pp. 533-562
Lichter et al, "High-Resolution Mapping of Human Chromosome 11 by in Situ Hybridization with Cosmid Clones," Science, vol. 247, Jan. 5, 1990, pp. 64-69
Arnoldus et al, "Detection of the Philadelphia Chromosome in Interphase Nuclei (With 2 Color Plates)," Cytogenet. Cell Genet., vol. 54, 1990, pp. 108-111
Bergerheim et al, "Deletion Mapping in Human Renal Cell Carcinoma," Cancer Res., vol. 49, Mar. 1989, pp. 1390-1396
Kievits et al, "Direct Nonradioactive In Situ Hybridization of Somatic Cell Hybrid DNA to Human Lymphocyte Chromosomes," Cytometry, vol. 11, 1990, pp. 105-109
Pinkel et al, "Fluorescence in situ Hybridization with Human Chromosome-Specific Libraries: Detection of Trisomy 21 and Translocations of Chromosome 4," PNAS (USA), vol. 85, Dec. 1988, pp. 9138-9142
Lichter et al, "Is Non-Isotopic in situ Hybridization Finally Coming of Age?," Nature, vol. 345, May 1990, pp. 93-94
Gray et al, "Fluorescence Hybridization to Human Chromosome 21 Using Probes From A Charon 21 A Library," Cytometry, (Suppl. 1), 1987, Abst. 19, p. 4
Bar-Am et al, "Detection of Amplified DNA Sequences in Human Tumor Cell Lines by Fluorescence In Situ Hybridization," Genes, Chromosomes & Cancer, vol. 4, 1982, pp. 314-320
Roelofs et al, "Gene Amplification in Human Cells May Involve Interchromosomal Transposition and Persistence of the Original DNA Region," The New Biologist, vol. 4, No. 1, (Jan. 1992), pp. 75-86
Smith et al, "Distinctive Chromosomal Structures Are Formed Very Early in the Amplification of CAD Genes in Syrian Hamster Cells," Cell, vol. 63, (Dec. 21, 1990), pp. 1219-1227
Trask et al, "Early Dihydrofolate Reductase Gene Amplification Events in CHO Cells Usually Occur on the Same Chromosome Arm as the Original Locus," Genes & Development, vol. 3, (1989), pp. 1913-1925
Windle et al, "A Central Role for Chromosome Breakage in Gene Amplification, Deletion Formation, and Amplicon Integration," Genes & Development, vol. 5, (1991), pp. 160-17
September 5, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
