Method of making nanoparticulate X-ray blood pool contrast agents using high molecular weight nonionic surfactants
Patent 5447710 Issued on September 5, 1995. Estimated Expiration Date: 
May 13, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 13, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesIodinated contrast agent for radiography Process for the preparation of activated pharmaceutical compositions Process of producing Mg2 Si-containing alloys Surface modified drug nanoparticles Patent #: 5145684 InventorsApplicationNo. 242492 filed on 05/13/1994US Classes:424/9.455, Carbonyl of a carboxylic acid or salt thereof attached directly to the benzene ring424/9.4, X-ray contrast imaging agent (e.g., computed tomography, angiography, etc.)424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/499, Contains proteins or derivative or polysaccharides or derivative514/5, Iodine containing514/718, Plural oxygens514/975CHARACTERIZED BY THE DESIGNATED SURFACTANT USEDExaminersPrimary: Hollinden, Gary E.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 049/04A61K 009/14 AbstractThe present invention is directed to a composition comprised of nanoparticles containing an x-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith.The present invention is also directed to a method for making nanoparticles comprising(i) contacting said nanoparticle containing an x-ray diagnostic compound with a high molecular weight nonionic surfactant for a time and under conditions sufficient to form a nanoparticle with the surfactant adsorbed on the surface thereof; and(ii) contacting the so treated nanoparticle with a cloud point modifier for a time and under conditions sufficient to form a nanoparticle containing an x-ray diagnostic compound, having a nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith.The present invention is still further directed to a method for diagnostic imaging for use in medical procedures comprising administering to the body of a test subject in need of an x-ray an effective contrast producing amount of a composition comprised of nanoparticles containing an x-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith. | |
