U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Automated molecular biology laboratory

Patent 5443791 Issued on August 22, 1995. Estimated Expiration Date: Icon_subject August 22, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

1180665

2579724

3754444

One-way evacuated tube stopper
Patent #: 4134512
Issued on: 01/16/1979
Inventor: Nugent

Apparatus for performing tests and measurements on liquid samples
Patent #: 4224278
Issued on: 09/23/1980
Inventor: Hogen Esch

Level sensor apparatus and method
Patent #: 4326851
Issued on: 04/27/1982
Inventor: Bello ,   et al.

Method and apparatus for calibrating a robot to compensate for inaccuracy of the robot
Patent #: 4362977
Issued on: 12/07/1982
Inventor: Evans ,   et al.

Liquid handling apparatus
Patent #: 4422151
Issued on: 12/20/1983
Inventor: Gilson

Stopper for containers for use in analyses
Patent #: 4515752
Issued on: 05/07/1985
Inventor: Miramanda

Valve assembly
Patent #: 4535818
Issued on: 08/20/1985
Inventor: Duncan ,   et al.

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Inventors

Assignee

Application

No. 927254 filed on 08/07/1992

US Classes:

422/65, Means is conveyor and rack73/864.11, With suction applying and liquid discharge means73/864.24, Pipette longitudinally movable73/864.25, And transversely movable422/63, Sample mechanical transport means in or for automated analytical system422/67, With specific analytical program control means422/100, Pipette or other volumetric fluid transfer means422/104, Holder, support, housing, or hood422/916, Closing or opening means, e.g., corks, bungs [B01L 3/14C]435/809, INCUBATORS OR RACKS OR HOLDERS FOR CULTURE PLATES OR CONTAINERS436/54, With aspirator of claimed structure436/180, Volumetric liquid transfer436/526, Magnetic700/83, Having operator control interface (e.g., control/display console)901/46SENSING DEVICE

Examiners

Primary: Housel, James C.
Assistant: Soderquist, Arlen

Attorney, Agent or Firm

Foreign Patent References

  • 136126 EP. 04/13/1985
  • 0209490 EP 01/13/1987
  • 63-195572 JP 08/13/1988
  • 8301912 WO 06/13/1983

International Classes

G01N 021/01
G01N 035/08
G01N 001/10
G01N 021/11

Abstract

A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for programming and editing. A gauge block registered on the worksurface provides for calibration using the sensing tip, and register cavities on the worksurface provide for modular stations. There is a wash station fop the pipette tip on the worksurface. An automated laboratory based on the liquid-handling system has heating and cooling and a sealable incubation station as well as a magnetic separation station. Methods are disclosed using the apparatus to convey droplets of liquid, to aspirate with minimum tip contamination, to mix liquids in containers, and to validate the worksurface. A duck-billed closure is disclosed for minimizing evaporation and cross-contamination during processing, and is a part of a container disclosed for storing and transporting liquids.

Other References

  • Severns et al. "Pipette cleaning in automated systems" J. of Automatic Chemistry 1986, 8, 135-141
  • Wilson et al. "Automation of Dideoxynucleotide DNA Sequencing Reactions Using a Robotic Workstation" BioTechniques, 1988, 6, 776-787
  • Connell et al. "Automated DNA Sequence Analysis" BioTechniques, 1987, 5, 342-348
  • McBride et al. "A New, Reliable Cartridge for Rapid Purification of Synthetic DNA" BioTechniques, 1988, 6, 362-367
  • Wilson, R K et al. Chemical Abstracts, vol. 109, 1988, abstract #223942d
  • R. A. Zeineh American Laboratory 1976, 8, 51-53
  • J. L. Guesdon et al. Immunochemistry 1977, 14, 443-447
  • D. S. Ithakissios et al. Clin. Chem. 1977, 23, 2072-2079
  • D. O. Kubiatowicz et al. J. Nucl. Med. 1978, 19, 854-857
  • A. Wada et al. Rev. Sci. Instrum. 1983, 54, 1569-1572
  • W. J. Martin et al. Bio/Technology 1985, 3, 911-915
  • Vernay catalog Verney Laboratories, Inc Yellow Springs, Ohio
  • W. J. Martin et al. J. Phys. E: Sci. Instrum. 1987, 20, 22-26
  • R. Frank et al. Bio/Technology 1988, 6, 1211-1213
  • J. Shigeura Proc. 5th International Symp. Lab. Robotics 1989 39-71
  • U. Schroder et al, Clin. Chem. 1990, 36, 1282-128
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