U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Biocompatible ocular implants

Patent 5443505 Issued on August 22, 1995. Estimated Expiration Date: Icon_subject November 15, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Ocular drug delivery device
Patent #: 4014335
Issued on: 03/29/1977
Inventor: Arnold

Ocular therapeutic system manufactured from copolymer
Patent #: 4052505
Issued on: 10/04/1977
Inventor: Higuchi ,   et al.

Ocular therapeutic system with selected membranes for administering ophthalmic drug
Patent #: 4057619
Issued on: 11/08/1977
Inventor: Higuchi ,   et al.

Selective administration of drug with ocular therapeutic system
Patent #: 4186184
Issued on: 01/29/1980
Inventor: Zaffaroni

Ocular therapeutic system for dispensing a medication formulation
Patent #: 4190642
Issued on: 02/26/1980
Inventor: Gale ,   et al.

Drug delivery system for controlled ocular therapy
Patent #: 4281654
Issued on: 08/04/1981
Inventor: Shell ,   et al.

Method for treating intraocular malignancies
Patent #: 4300557
Issued on: 11/17/1981
Inventor: Refojo ,   et al.

Medication indicated for ocular hypertension
Patent #: 4303637
Issued on: 12/01/1981
Inventor: Shell ,   et al.

Ocular insert housing steroid in two different therapeutic forms
Patent #: 4304765
Issued on: 12/08/1981
Inventor: Shell ,   et al.

Biodegradable ocular implants
Patent #: 4853224
Issued on: 08/01/1989
Inventor: Wong

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Inventors

Assignee

Application

No. 153184 filed on 11/15/1993

US Classes:

623/4.1, EYE PROSTHESIS (E.G., LENS OR CORNEAL IMPLANT, OR ARTIFICIAL EYE, ETC.)424/427, Ocular424/428Bioerrodable, resorbable, or dissolving

Examiners

Primary: Shay, Randy C.

Attorney, Agent or Firm

International Class

A61F 002/14

Abstract

Implants comprising active agents are employed for introduction into a suprachoroidal space or an avascular region of an eye for therapeutic purposes. The administration of drags is controlled and maintained for long periods of time, while ensuring the substantial absence of significant levels outside the site of administration.

Other References

  • Heller, "Controlled Drug Release from Poly(Ortho Esters)-- A Surface Eroding Polymer," J. Controlled Release (1985) 2: 167-177
  • Leong et al., "Polyanhydrides for Controlled release of Bioactive Agents," Biomaterials (1986) 7: 364-371
  • Heller, "Bioerodible Hydrogels," in Hydrogels in Medicine of Pharmacy (H. A. Pepper Ed., CRE Press, Boca Raton, Fla.)(1987) 137-149
  • Liu et al., "Intravitreal Liposome-Encapsulated Trifuluorothymidine in a Rabbit Model," Opthamology (1985) 94: 1155-1159
  • Smith et al., "Intravitreal Sustained-Release Ganciclovir," Arch. Opthamology (1992) 110: 255-25
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