U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Automation of plasma sequestration

Patent 5437598 Issued on August 1, 1995. Estimated Expiration Date: Icon_subject January 21, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3655123

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Method and apparatus for separating whole blood into its components and for automatically collecting one component
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Blood separation system
Patent #: 5102407
Issued on: 04/07/1992
Inventor: Carmen, et al.

Bottom blood bag separation system
Patent #: 5154716
Issued on: 10/13/1992
Inventor: Bauman, et al.

Centrifuge drum for concentrating suspended solids
Patent #: 5199938
Issued on: 04/06/1993
Inventor: Kohlstette, et al.

Method and apparatus for the separation of blood into its components
Patent #: 5281342
Issued on: 01/25/1994
Inventor: Biesel, et al.

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Inventor

Assignee

Application

No. 185487 filed on 01/21/1994

US Classes:

494/1, WITH CONDITION RESPONSIVE MEANS494/10, WITH MEANS FOR INDICATING, INSPECTING, MEASURING, SIGNALING OR TESTING604/6.04Plasma

Examiners

Primary: Scherbel, David A.
Assistant: Till, Terrence R.

Attorney, Agent or Firm

Foreign Patent References

  • WO88/05691 WO. 08/19/1988

International Classes

B04B 009/10
A61M 001/36

Abstract

A plasma sequestration system having a volume control system is provided. When a calculated volume of whole blood has been processed, the system switches from a fill to an empty cycle. The termination point is calculated in advance, based on the desired composition of the collected plasma, thus improving process control and product uniformity. The system is automated or partially automated using an optical sensor or marker to monitor the volume of packed red blood cells. When the red cells reach the marker or sensor, a signal is sent to the control system which then calculates the required fill volume. Processing continues until the calculated fill volume is reached, at which time the system automatically stops the collection cycle. The system also provides for two speed operation of the centrifuge as a safeguard against foaming which may result in aerosol formation and blood trauma. Foaming is reduced by reducing centrifuge speed as the packed red blood cells approach the stationary deflector in the centrifuge bowl.

Other References

  • T. Simon et al., "Storage and Transfusion of Platelets Collected by an Automated Two-Stage Apheresis Procedure", (1992) Transfusion 32:624-628
  • C. F. Hogman, "The Bottom and Top System: A New Technique for Blood Component Preparation and Storage", (1988), Vox Sang 55:211-217
  • R. G. Strauss et al., "Comparison of autosurge versus surge protocols for discontinuous-flow centrifugation plateletapheresis", (1987), Transfusion 27:6 pp. 499-501
  • J. P. AuBuchon et al. "Optimization of Parameters for Maximization of Plateletpheresis and Lymphocytapheresis Yields on the Haemonetics Model V50", (1986), J. Clin. Apheresis 3:103-10
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