Immortal human mammary epithelial cell lines
Patent 5436152 Issued on July 25, 1995. Estimated Expiration Date: 
July 25, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 25, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesEnhanced growth medium and method for culturing human mammary epithelial cells Continuous human cell lines and method of making same Immortal human mammary epithelial cell lines Patent #: 5026637 InventorsApplicationNo. 702808 filed on 05/20/1991US Classes:435/371Epithelial origin or derivativeExaminersPrimary: Robinson, Douglas W.Assistant: Weber, Susan M. Attorney, Agent or FirmInternational ClassesC12N 005/00C12N 005/08 AbstractImmortalized human epithelial cell sublines are provided. The novel cell lines do not undergo terminal differentiation and senescence upon exposure to high calcium concentrations. The novel cells exhibit positive reactivity with milk-fat globule membrane antigen and cytokeratin anti-serum. The cells are non-tumorigenic in athymic mice, and exhibit both three-dimensional growth in collagen and dome formation in confluent cultures. The cell sublines demonstrate growth control by hormones and growth factors. The novel cell sublines are useful in evaluating the capacity of preselected agents to bring about a change in epithelial cell growth and in the production of proteins.Other References
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