Sustained release suppositories and a process for preparation
December 15, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2538127 3870790 Enteral pharmaceutical compositions Controlled release suppositories Pharmaceutical vehicle Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose Medicament capsules for rectal application Controlled release suppositories consisting essentially of a linear polymer particularly, polyvinyl pyrrolidones Patent #: 4406883 InventorsAssigneeApplicationNo. 990888 filed on 12/15/1992US Classes:424/436, Anal, rectal (e.g., suppositories, etc.)424/422, Implant or insert424/434, Mucosal (e.g., nasal, etc.)514/966RECTALExaminersPrimary: Phelan, D. GabrielleAttorney, Agent or FirmForeign Patent References
International ClassA61M 031/00Foreign Application Priority Data1991-12-20 NLAbstractA sustained release suppository comprising in a usual suppository basea) a water-soluble therapeutically active substance, the average particle size of which is smaller than 20 μm,b) a physiologically acceptable organic substance which is swellable in contact with water, andc) hydrophobic silicium dioxide.The suppository base is usually a fat having a melting range of from 29° to 38° C. As ingredient b) cellulose derivatives such as hydroxypropylmethylcellulose may be used, in a quantity of from 5 to 40% by weight, preferably 9 to 15% by weight. Ingredient c) is preferably used in a quantity of from 3 to 6% by weight. Also a process for manufacturing the suppositories is described.Other References
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