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Neuroprotective pharmaceutical compositions of 4-phenylpinene derivatives and certain novel 4-phenylpinene compounds

Patent 5434295 Issued on July 18, 1995. Estimated Expiration Date: Icon_subject February 7, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Pinene derivatives and pharmaceutical compositions containing the same
Patent #: 4282248
Issued on: 08/04/1981
Inventor: Mechoulam ,   et al.

Terpene sulfonate hydrotropes Patent #: 4528144
Issued on: 07/09/1985
Inventor: Gutierrez ,   et al.

Inventors

Assignee

Application

No. 192924 filed on 02/07/1994

US Classes:

560/141, Rings bonded directly to each other in phenolic moiety560/255, Plural rings in alcohol moiety568/734Bicyclo ring system

Examiners

Primary: Prescott, Arthur C.

Attorney, Agent or Firm

International Classes

A61K 031/22
A61K 031/05
C07C 069/01
C07C 039/17

Abstract

The present invention provides certain novel 4-phenylpinene derivatives, and teaches how to use said novel derivatives and related compounds in pharmaceutical compositions that have utility in treating various pathological conditions associated with damage to the central nervous system. The active ingredient of the pharmaceutical compositions according to the present invention is a compound of the formula: ##STR1## wherein A - - - B designates an optional double bond, R1 designates a variety of organic moieties, G designates alkyl, halogen, or various oxy groups, and R3 designates various alkyl groups, ether groups, or combinations thereof.

Other References

  • Mechoulam et al., Prog. Med. Chem., 24: 159-207 (1987)
  • Devane et al., J. Med. Chem., 35: 2065-2069 (1992)
  • Feigenbaum et al., Proc. Natl. Acad. Sci. U.S. 86: 9584-9587 (1989)
  • Shohami et al., J. Neurotrauma, 10: 109-119 (1993)
  • Bar-Joseph et al., J. Neurochem., 61: 685A (1993)
  • Choi, Neuron 1: 623-634 (1988)
  • Rogawski, TIPS 14: 325-331 (1993)
  • Little et al., J. Pharmacol. Exp. Ther., 247: 1046-1051 (1988)
  • D'Ambra et al., J. Med. Chem., 35: 124-135 (1992)
  • Mechoulam et al., J. Med. Chem., 33: 1037-1043 (1990)
  • McIntosh, J. Neurotrauma, 10: 215-243 (1993)
  • Eshhar, et al., 5: 237-240 (1993)
  • Nadler, et al., 622: 79-85 (1993
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