Immunoprotective genetically-detoxified mutants of pertussis toxin
Patent 5433945 Issued on July 18, 1995. Estimated Expiration Date: November 20, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/185.1, Amino acid sequence disclosed in whole or in part; or conjugate, complex, or fusion protein or fusion polypeptide including the same424/190.1, Disclosed amino acid sequence derived from bacterium (e.g., Mycoplasma, Anaplasma, etc.)424/240.1, Bordetella (e.g., Bordetella pertussis, etc.)530/350PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES
A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this information, defined mutant holotoxins have been produced by site directed mutagenesis of the toxin gene. A number of these holotoxin analogues are detoxified, retain an immunodominant S1 epitope, are immunogenic and are protective in the standard pertussis vaccine potency test in mice.
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November 20, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
