Patent ReferencesMethod for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same Methods of and systems for examining tissue perfusion using ultrasonic contrast agents Patent #: 5255683 InventorApplicationNo. 153930 filed on 11/15/1993US Classes:600/458Contrast enhancementExaminersPrimary: Manuel, GeorgeInternational ClassA61B 008/00AbstractA method and apparatus for characterizing the time and frequency response of an ultrasonically reflective contrast agent is disclosed. An ultrasonically reflective contrast agent is injected, under constant pressure, into a fluid flowing through a pump flow circuit. The fluid and the ultrasonically reflective contrast agent are uniformly mixed in a mixing chamber, and the uniform mixture is passed through a contrast agent chamber. The contrast agent chamber is acoustically and axially interposed between an ultrasonic transducer chamber and an acoustic isolation chamber. A pulse of ultrasonic energy is transmitted into the contrast agent chamber from the ultrasonic transducer chamber. An echo waveform is received from the ultrasonically reflective contrast agent, and it is analyzed to determine the time and frequency response of the ultrasonically reflective contrast agent. | |