Biodegradable bursting release system
July 4, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesControlled release delivery system by an osmotic bursting mechanism Albumin medicament carrier system Osmotic bursting drug delivery device Method of delivering drug with aid of effervescent activity generated in environment of use Method and system for the controlled release of biologically active substances to a body fluid Biodegradable, implantable drug delivery device, and process for preparing and using the same Osmotic drug delivery system Biodegradable, implantable drug delivery depots, and method for preparing and using the same Method and system for the controlled release of biologically active substances to a body fluid Adherent controlled release microbiocides containing hydrolyzable silanes and organic titanium compounds InventorsAssigneeApplicationNo. 852372 filed on 03/13/1992US Classes:424/426, Errodable, resorbable, or dissolving424/468, Sustained or differential release type424/476, Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof (e.g., chocolate)424/497Containing solid synthetic polymersExaminersPrimary: Page, Thurman K.Assistant: Benston, William E. Jr. Attorney, Agent or FirmInternational ClassA61F 002/00AbstractA biodegradable polymeric multiphasic release system of one or more biodegradable bursting units capable of delivering biologically active substances in a burst or pulse at predetermined times and a method for constructing those units is disclosed. The individual bursting units of the system may take the form of a biodegradable, membrane coated capsule surrounding a core material which may include an active agent. The membrane ruptures after a predetermined time upon exposure to water or bodily, or other aqueous environmental fluids. The bursting units may be used in any situation in which a controlled pulsed release of an active substance is desired. The predetermined time release of each bursting unit is controlled by the composition of the core material, the initial radius and wall thickness of the membrane and the porosity of the membrane. The core material may also contain a chemical composition which generates gas as fluid is drawn into the bursting unit thus adding an additional design variable for predetermining bursts. | |
