U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

On-demand iontophoretic system

Patent 5427585 Issued on June 27, 1995. Estimated Expiration Date: Icon_subject March 29, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Epidermal iontophoresis device
Patent #: 4141359
Issued on: 02/27/1979
Inventor: Jacobsen ,   et al.

Fluid self-sealing bioelectrode
Patent #: 4166457
Issued on: 09/04/1979
Inventor: Jacobsen ,   et al.

Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands
Patent #: 4702732
Issued on: 10/27/1987
Inventor: Powers ,   et al.

Method and apparatus for iontophoretic drug delivery
Patent #: 4722726
Issued on: 02/02/1988
Inventor: Sanderson ,   et al.

System and method for controlling rate of electrokinetic delivery of a drug
Patent #: 4808152
Issued on: 02/28/1989
Inventor: Sibalis

Transdermal multipolymer drug delivery system
Patent #: 4814168
Issued on: 03/21/1989
Inventor: Sablotsky ,   et al.

Plaster structural assembly for iontophoresis
Patent #: 4842577
Issued on: 06/27/1989
Inventor: Konno ,   et al.

User-activated transdermal therapeutic system
Patent #: 4917676
Issued on: 04/17/1990
Inventor: Heiber, et al.

Bandage for transdermal delivery of systemically-active drug
Patent #: 4917688
Issued on: 04/17/1990
Inventor: Nelson, et al.

Transdermal drug patch with microtubes
Patent #: 4921475
Issued on: 05/01/1990
Inventor: Sibalis

More ...

Inventor

Application

No. 038285 filed on 03/29/1993

US Classes:

604/20, Infrared, visible light, ultraviolet, X-ray or electrical energy applied to body (e.g., iontophoresis, etc.)607/151Battery-holding grip

Examiners

Primary: Rosenbaum, C. Fred
Assistant: Rafa, Michael

International Class

A61N 001/30

Abstract

A transdermal medication system wherein said medication is selectively dispensed on-demand from multiple reservoirs within a disposable patch so as to vary the drug choice and the drug concentration, and thereby the regimen and release rate. In a preferred embodiment electric resistance heating activates multiple heat-shrink polymer reservoirs into an absorbent layer for transdermal passage. An embodiment of the invention dispenses a heated moisturizing fluid to facilitate transdermal transfer. In another embodiment, depletion indication is provided.

Other References

  • Berner & Dinh, Fundamental Concepts in Controlled Release, pp. 2-4, "Treatise on Controlled Drug Delivery", Edited by Agis Kydonieus, Marcel Dekker, Inc. 1992
  • Robert D. Lowry, "Packaging Monograph No. 1", 1963, p. 8, Packaging Institute
  • J. Hadgraft & R. H. Guy, "Physicochemical Models for Percutaneous Absorption", 0097-6156/87/0348-0084 ACS, also published by Chapter 6 of Controlled-Release Technology, pp. 84-97, 1987
  • Y. W. Chien & C. Lee, "Transdermal Drug Delivery System with Enhanced Skin Permeability", 0097-6156/87/0348-0281 ACS, also published as Chapter 21 of Controlled-Release Technology, pp. 281-300, 1987
  • C. B. Rosdahl, RN, "Textbook of Basic Nursing", Lippincott, p. 320, 1989
  • Nozawa I. Suzuki Y. Sato S. Sugibayashi K. Morimoto Y. "Preparation of thermo-responsive membranes. II." Journal of Biomedical Materials Research. [JC:hjj] 25(5):577-88, 1991 May
  • Sasaki H. Kojima M. Nakamura J. Shibasaki J. "Enhancing effect of combining two pyrrolidone vehicles on transdermal drug delivery." Journal of Pharmacy & Pharmacology. [JC:jnr] 42(3):196-9, 1990 Ma
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