Patent 5427585 Issued on June 27, 1995. Estimated Expiration Date: March 29, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
A transdermal medication system wherein said medication is selectively dispensed on-demand from multiple reservoirs within a disposable patch so as to vary the drug choice and the drug concentration, and thereby the regimen and release rate. In a preferred embodiment electric resistance heating activates multiple heat-shrink polymer reservoirs into an absorbent layer for transdermal passage. An embodiment of the invention dispenses a heated moisturizing fluid to facilitate transdermal transfer. In another embodiment, depletion indication is provided.
Other References
Berner & Dinh, Fundamental Concepts in Controlled Release, pp. 2-4, "Treatise on Controlled Drug Delivery", Edited by Agis Kydonieus, Marcel Dekker, Inc. 1992
Robert D. Lowry, "Packaging Monograph No. 1", 1963, p. 8, Packaging Institute
J. Hadgraft & R. H. Guy, "Physicochemical Models for Percutaneous Absorption", 0097-6156/87/0348-0084 ACS, also published by Chapter 6 of Controlled-Release Technology, pp. 84-97, 1987
Y. W. Chien & C. Lee, "Transdermal Drug Delivery System with Enhanced Skin Permeability", 0097-6156/87/0348-0281 ACS, also published as Chapter 21 of Controlled-Release Technology, pp. 281-300, 1987
C. B. Rosdahl, RN, "Textbook of Basic Nursing", Lippincott, p. 320, 1989
Nozawa I. Suzuki Y. Sato S. Sugibayashi K. Morimoto Y. "Preparation of thermo-responsive membranes. II." Journal of Biomedical Materials Research. [JC:hjj] 25(5):577-88, 1991 May
Sasaki H. Kojima M. Nakamura J. Shibasaki J. "Enhancing effect of combining two pyrrolidone vehicles on transdermal drug delivery." Journal of Pharmacy & Pharmacology. [JC:jnr] 42(3):196-9, 1990 Ma