Method of screening for arterial chlamydial granuloma
Patent 5424187 Issued on June 13, 1995. Estimated Expiration Date: June 13, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
435/6, Involving nucleic acid435/4, MEASURING OR TESTING PROCESS INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITION OR TEST STRIP THEREFORE; PROCESSES OF FORMING SUCH COMPOSITION OR TEST STRIP435/7.1Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay
Method of diagnosing arterial chlamydial granuloma by detecting in a biological sample both a first marker associated with Chlamydia pneumoniae and a second marker associated with arterial granuloma. Therapeutic composition for treating arterial chlamydial granulomatous disease, including an anti-Chlamydia pneumoniae agent and a granuloma inhibitor.
Other References
Shor, A., J.G., Brunton, J.D. Cantrell, and G. E. H. van Sittert. A preliminary study of structures found in human coronary artery lesions. Electron Microscopic Society of South Africa 21:241-242, Dec. 1991
Dictionary of Immunology. W J Herbert et al. eds. (1985) p. 89
Dictionary of Microbiology and Molecular Biology, P. Singleton et al. eds (1991) p. 395
Nevill, Woolf, "Pathology of Atherosclerosis", Butterworths Scientific Co., Ltd. pp. 1-2 and pp. 47-65 (1982)
Haust, M. D. The morphogenesis and fate of potential and early atherosclerotic lesions in man. Human Pathology 2: 1-29 (1971)
Kuo, C-C., E. Y. Chi, and J. T. Grayston. Ultrastructural study of entry of Chlamydia strain TWAR into HeLa cells. Infect. Immun. 56: 1668-1672 (1988)
Bocan, T. M. A. and J. R. Guyton. Human aortic fibrolipid lesions: Progenitor lesions for fibrous plaques, exhibiting early formation of the cholesterol-rich core. Am. J. Pathol. 120: 193-206 (1985)
Gerrity, R. G. The role of the monocyte in atherogenesis. I. Transition of blood-borne monocytes into cells in fatty lesions. Am. J. Pathol. 103: 181-190 (1981)
Gerrity, R. G. The role of the monocyte in atherogenesis. II. Migration of foam cells from atherosclerotic lesions. Am. J. Pathol;. 103: 191-200 (1981)
Gorstein, F. Ubiquitous smooth muscle cell. Human Pathology 20: 1035-1036 (1989)
Orekhov, A. N., E. R. Andreeva, A. V. Krushinsky, I. D. Novikov, V. V. Tertov, G. V. Nestaiko, A. Khasimov, V. S. Repin, and V. N. Smirnov. Intimal cells and atherosclerosis, Am. J. Pathol. 125: 402-415 (1986)
Parums, D. and M. J. Mitchinson. Demonstration of Immunoglobulin in the neighbourhood of advanced atherosclerotic plaques. Atherosclerosis 38: 211-216 (1981)
Ramshaw, A. L. and D. V. Parums. Immunohistochemical characterization of inflammatory cells associated with advanced atherosclerosis. Histophatol. 17: 543-552 (1990)
Manor, E. and I. Sarov. Fate of Chlamydia trachomatis in human monocytes and monocyte-derived macrophages. Infect. Immun. 54: 90-95 (1986)
Hajjar, D. P. Virus-induced atherosclerosis: Herpesvirus infection alters aortic cholesterol metabolism and accumulation. Am. J. Pathol. 122: 62-70 (1986)
Melnick, J. L., E. Adam, and M. E. DeBakey. Special role of cytomegalovirus in atherogenesis. JAMA 263: 2204-2207 (1990)
Grayston, JT, Kuo CC, Campbell LA, Wang SP. Chlamydia pneumoniae sp. nov. for Chlamydia sp. strain TWAR. Int. J. Syst. Bacteriol. 1989; 39: 88-90
Chi EY, Kuo, CC, Grayston T.J. Unique ultrastructure in Elementary Body of Chlamydia sp. strain TWAR. Int. J. Syst. Bacteriol. 1987; 169:3757-3673
Grayston TJ, Campbell LA, Kuo CC, Mordhorst CH, Saikku P, Thom DH, Wang SP. A New Respiratory Tract Pathogen. Chlamydia pneumoniae Strain TWAR. J. Infect. Dis. 1990; 161: 618-625
Saikku P, Mattila K, Nieminen MS, Huttunen JK, Leinonen M, Ekman MR, Makela PH, Valtonen V. Serological evidence of an association of a novel Chlamydia, TWAR with chronic Coronary Heart Disease and Acute Myocardial Infarction. Lancet, 1988; 2: 983-985
Thom DH, Wang SP, Grayston JT, Siscovick DS, Steward DK, Kronmal RA, Weiss NS. Chamydia pneumoniae strain TWAR antibody and angiographically demostrated coronary artery disease. Arteriosclerosis and Thrombosis 1991; 11: 547-551
Kuo CC, Chen HH, Wang SP, Grayston T. Identification of New Group of Chlamydia psittaci Strains called TWAR. J. Clin. Microbiol., 1986; 24: 1034-1037
Guyton JR, Klemp KF. The Lipid Rich Core Region of Human Atherosclerotic Fibrous Plaques. Am. T. Pathol., 1989; 134:705-717
Sutton GC, Demakis JA, Anderson TO, Morrissey RA. Serologic evidence of a sporadic outbreak in Illinois of infection by Chlamydia (psittacosis-LGV agent) in patients with primary myocardial disease and respiratory disease. Am. Heart J 1971; 81: 597-607
Grayston TT, Mordhorst CH, Wang SP. Childhood myocarditis associated with Chlamydia tracomatis infection. JAMA 1981; 246: 2823-2827
Jones RB, Priest JB, Kuo CC. Subacute chlamydial endocarditis. JAMA 1982; 247: 655-658
Marrie TJ, Harczy M, Mann OE, Landymore RW, Raza A, Wang SP, Grayston JT. Culture-negative endocarditis probaly due to Chlamydia pneumoniae. J. Infect Dis 1990; 161: 127-129
Benditt EP, Barrett T, McDougall JK. Viruses in the etiology of atherosclerosis. Proc. Natl. Acad. Sci. USA. 1983; 80: 6386-6389
Saikku P, Leinonen M, Tenkanen L, Linnanmaki E, Ekman MR, Manninen V, Manttari M, Frick MH, Huttunen JK, Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study. Ann Int. Med 1992; 116:273-278
Campbell LA, Perez-Melgosa M, Hamilton DJ, Kuo CC, Grayston JT, Detection of Chlamydia pneumoniae by polymerase chain reaction. J. Clin. Microbiol 1992;30:434-439
Kuo CC, Grayston JT, A sensitive cell line, HL cells, for isolation and propagation of Chlamydia pneumoniae strain TWAR. J. Infect Dis 1990;162:755-758
Kuo CC, Grayston JT, Factors affecting viability and growth in HeLa 229 cells of Chlamydia sp. strain TWAR. J. Clin. Microbiol. 1988;26:812-815
Kuo CC, Cultures of Chlamydia trachomatis in mouse peritoneal macrophages: Factors affecting organism growth. Infect. Immun. 1978; 20:439-445
Yong, EC, Chi EY, Kuo CC, Differential antimicrobial activity of human mononuclear phagocytes against the human biovars of Chlamydia trachomatis. J. Immunol 1987;139:1297-1302
Chen WJ, Kuo CC, A mouse model of pneumonitis induced by Chlamydia trachomatis: Morphologic, microbiologic and immunlogic studies. Am J Pathol 1980;100:365-377
Rothermel CD, Schachter J, Lavrich P, Lipsitz EC, Francus T, Chlamydia trachomatis-induced production interleukin-1 by human monocytes. Infect Immun 1989;57:2705-2711
Kuo CC, Grayston JT, In vitro drug susceptibility of Chlamydia sp. strain TWAR. Antimicrob Agent Chemother 1988; 32:257-258
Lipsky BA, Tack KJ, Wang SP, Kuo CC, Grayston JT, Ofloxacin treatment of a Chlamydia pneumoniae (strain TWAR) lower respiratory tract infections. Am. J. Med 1990;89:722-724
Grayston, J. T., Kuo, C. C., Wang, S. P., Altman, J. A new Chlamydia psittaci strain, TWAR, isolated in acute respiratory tract infections. New. Engl. J. Med. 1986;315:161-168
Kleemola, M., Saikku, P., Visakorpi, R., Wang, S.P. Epidemics of pneumonia caused by TWAR, A new chlamydia organism, in military trainees in Finland. J. Infect. Dis. 1988; 157:230-236
Campbell, L. A., Kuo, C. C., Thissen, R. W. and Grayston,J. T. Isolation of a gene encoding a Chlamydia sp. strain TWAR protein that is recognized during infection of humans. Infect. Immun. 1989;57:71-75
Ladany, S., Black, C. M., Farshy, C. E., Ossewaarde, J. M. and Barnes, R. C. Enzyme immunoassay to determine exposure to Chlamydia pneumoniae (Strain TWAR). J. Clin. Microbiol. 1989;27:2778-2783
Fu, Y., Baumann, M., Kosma, P., Brade, L. and Brade, H. A synthetic glycoconjugate representing the genus-specific epitope of Chlamydial lipopolysaccharide exhibits the same specificity as its natural counterpart. Infect. Immun. 1992;60:1314-1321
Stuart, E. S., Wyrick, P. B., Choong, J., Stoler, S. B., MacDonald, A. B. Examination of chlamydial glycolipid with monoclonal antibodies: cellular distribution and epitope binding. Immunol. 1991; 74: 740-747
Karimi, S. T., Schloemer, R. H. and Wilde, C. E. Accumulation of infected cells. Infect. Immun. 1989; 57: 1780-1785
Brade, L., Holst, O., Kosma, P., Zhang, Y-X., Paulsen, H. Krausse, R., and Brade, H. Characterization of murine monoclonal and murine, rabbit, and human polyclonal antibodies against Chlamydial lipopolysccharide. Infect. Immun. 1990; 58: 205-213
Shor, A., Kuo, C. C., Patton, D. L., Fukushi, H., and Campbell, L. A. Detection of Chlamydia pneumoniae in the coronary artery atheroma plaque. 1992. Amer. Soc. Microbiol. Abstract #D-67, p. 107, General Meeting, New Orleans, La
Bobo, L., Coutlee, F., Yolken, R. H., Quinn, T., and Viscidi, R. P. Diagnosis of Chlamydia trachomatis cervical infection by detection of amplified DNA with an enzyme immunoassay. J. Clin. Microbiol. 1990, 28: 1968-1973
Holland, S. M., Taylor, H. R., Gaydos, C. A., Kappus, E. W. and Quinn, T. C. Experimental infection with Chlamydia pneumoniae in nonhuman primates. Infect. Immun. 1990, 58:593-597
Bell, T. A., Kuo, C.-C., Wang, S. P. and Grayston, J. T. Experimental infection of baboons (Papio cynocephalus anubis) with Chlamydia pneumoniae strain `TWAR`. J. Infection 1989, 19: 47-49
Koskenvuo, M. and Romanov, K., Lancet 1989, i: 158, and Saikku, P., Leinonen, M., Mattila, K., Ekman, M. R., Nieminen, M. S., Makela, P. H., Huttunen, J. K., and Valtonen, V., Lancet 1989, i: 158
Leinonen, M., Linnanmaki, E., Mattila, K., Nieminen, M. S., Valtonen, V., Leirisalo-Repo, M., and Saikku, P. Circulating immune complexes containing Chlamydial lipopolysaccharide in acute myocardial infarction. Microbial Pathogenesis 1990, 9: 67-73
Thom, D. H., Wang, S-P., Grayston, J. T., Siscovick, D. S., Stewart, D. K., Weiss, N. S., and Kronomal, R. A. The association between Chlamydia pneumoniae strain TWAR antibody and angiographically demonstrated coronary artery disease. Circulation 1991, 83: 736
Thom, D.H., Grayston, J.T., Wang, S-P., Kuo, C.C. and Altman, J. Chlamydia pneumoniae strain TWAR, Mycoplasma pneumoniae, and viral infections in acute respiratory disease in a University student health clinic population. Amer. J. Epidemiol. 1990, 132: 248-25
June 13, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
