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US Patent 5419760 - Medicament dispensing stent for prevention of restenosis of a blood vessel
US Patent Issued on May 30, 1995
Estimated Patent Expiration Date:
October 11, 2014Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
October 11, 2014Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractFollowing recanalization of a stenotic blood vessel, a photosensitizer is administered by means of a vaso-absorbable stent to maintain the photosensitizer concentration level in the atheromatous plaque and smooth muscle cells in the vicinity of the lesion for a period of 5-18 days, the period in which cell proliferation can occur. The Vaso-Absorbable Stent (VAST) is described along with the method for its use in Photoatherolytic (PAL) Therapy. The VAST device is used post cardiovascular intervention to: a) deliver a series of drugs to prevent cell proliferation leading to restenosis; and, (b) maintain the patency of the treated vessel and prevent elastic recoil of the vessel by providing support for the vessel wall; and c) deliver and maintain a level of photosensitizer to the treatment site which inhibits smooth muscle cell proliferation and, when activated by light energy, induces cell lysis. The photosensitizer inhibits smooth muscle cell proliferation and, thus, minimizes or eliminates the possibility of re-stenosis. The photosensitizer is then illuminated at the end of this period, thereby lysing the atheromatous plaque and smooth muscles. | InventorAssigneeApplicationNo. 320779 filed on 10/11/1994US Classes:604/8, DEVICES TRANSFERRING FLUIDS FROM WITHIN ONE AREA OF BODY TO ANOTHER (E.G., SHUNTS, ETC.)606/154, Bioabsorbable606/194, Inserted in vascular system623/1.42Drug deliveryField of Search604/8, DEVICES TRANSFERRING FLUIDS FROM WITHIN ONE AREA OF BODY TO ANOTHER (E.G., SHUNTS, ETC.)604/9, With flow control means (e.g., check valves, hydrocephalus pumps, etc.)604/10, With antisiphon means604/21, With tubular injection means inserted into body606/154, Bioabsorbable606/194Inserted in vascular systemExaminersPrimary: Rimell, SamAttorney, Agent or FirmUS Patent References3914802, 4512762, Method of treatment of atherosclerosis and a balloon catheter for sameIssued on: 04/23/1985 Inventor: Spears5019075, Method and apparatus for angioplasty Issued on: 05/28/1991 Inventor: Spears, et al.5019090, Radially expandable endoprosthesis and the like Issued on: 05/28/1991 Inventor: Pinchuk5064057, Support for anastomosing or connecting living organs Issued on: 11/12/1991 Inventor: Iwatsuki, et al.5085966, Non-aqueous dispersing agent and liquid developing agent for electrostatic photography Issued on: 02/04/1992 Inventor: Suzuki, et al.5112718, Liquid developer for electrostatic photography Issued on: 05/12/1992 Inventor: Kato, et al.5197977, Drug delivery collagen-impregnated synthetic vascular graft Issued on: 03/30/1993 Inventor: Hoffman, Jr., et al.5234456, Hydrophilic stent Issued on: 08/10/1993 Inventor: Silvestrini5236447Artificial tubular organ Issued on: 08/17/1993 Inventor: Kubo, et al. International ClassA61B 006/00 |
