Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
Patent 5410016 Issued on April 25, 1995. Estimated Expiration Date: March 1, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
528/354, From compound having -C-C(=O)-O-C- group as part of a heterocyclic ring, e.g., lactone, etc.128/898, Methods424/426, Errodable, resorbable, or dissolving424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)514/772.1, Aftertreated solid synthetic organic polymer (e.g., grafting, blocking, etc.)514/772.3, Solid synthetic organic polymer514/773, Peptide containing514/777, Carbohydrate or lignin, or derivative522/14, Specified rate-affecting material is an amide or tertiary amine522/26, Specified rate-affecting material is heterocyclic522/44, Containing C-CO-C(R)(OR) wherein R is organic, e.g., diethoxyacetophenone, etc.522/48, Quinone ring is part of polynuclear system, e.g., anthraquinone, etc.522/88, Processes involving carbohydrate as reactant or as solid polymer; or compositions therefore522/181, Ether group525/54.1, Containing chemically combined protein or biologically active polypeptide525/54.2, Previously formed solid polymer chemically reacted with carbohydrate or derivative525/408, Mixed with carboxylic acid or derivative or polymer derived therefrom525/413, Mixed with -O-C(=O)- or hal-C(=O)- reactant or polymer derived therefrom525/415, Solid polymer derived from carboxylic acid cyclic ester, e.g., lactone, etc.528/361From ether, metal alcoholate, or alcohol group-containing carboxylic acid; or from a derivative of a carboxylic acid which derivative contains an ether, metal alcoholate, or alcohol group
Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.
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March 1, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
