U.S. patents available from 1976 to present.
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Crystalline cephem acid addition salts and process for their preparation

Patent 5409918 Issued on April 25, 1995. Estimated Expiration Date: Icon_subject August 21, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Thiazolylacetamido compounds
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Inventor: Ochiai ,   et al.

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Patent #: 4264595
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Inventor: Numata ,   et al.

Cephem derivative
Patent #: 4278793
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Inventor: Durckheimer ,   et al.

3-Acetoxymethyl-7-(hydroxyiminoacetamido)-cephalosporanic acid derivatives
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Patent #: 4298606
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Thiazolylacetamido cephalosporin type compounds
Patent #: 4355160
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7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
Patent #: 4409215
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7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
Patent #: 4462999
Issued on: 07/31/1984
Inventor: Takaya ,   et al.

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Inventors

Application

No. 931505 filed on 08/21/1992

US Classes:

514/202, Additional hetero ring540/222Additional hetero ring containing

Examiners

Primary: Rizzo, Nicholas S.

Attorney, Agent or Firm

Foreign Patent References

  • 0034536A2 EP. 02/12/1981
  • 0034536B1 EP. 02/12/1981
  • 0029557A2 EP. 03/12/1981
  • 0049119A2 EP. 04/12/1982
  • 0134420A1 EP. 03/12/1985
  • 2556736A1 DE. 06/12/1976
  • 2560398C2 DE. 09/12/1983
  • 3804841 DE. 08/12/1989
  • 3809561 DE. 10/12/1989

International Classes

C07D 501/32
A61K 031/545

Foreign Application Priority Data

1989-06-13 DE

Abstract

Crystalline cephem acid addition salts of the general formula II ##STR1## pharmaceutical preparations effective against bacterial infections which contain such cephem derivatives, processes for the preparation of the cephem derivatives and the pharmaceutical preparations, and the use of the cephem derivatives for combating bacterial infections.

Other References

  • Chemical Abstracts vol. 115(8):78903(j) (1991)
  • Chemical Abstracts vol. 105(19):164392(s) (1986)
  • In Vivo Evaluation of Tigemonam, a Novel Oral Monobactam, Junius M. Clark et al., Antimicrobial Agents and Chemotherapy, vol. 31, No. 2, Feb. 1987, pp. 226-229
  • Pharmacokinetic and In Vivo Studies with Azithromycin (CP-62,993), a New Macrolide with an Extended Half-Life and Excellent Tissue Distribution, Girard et al., Antimicrobial Agents and Chemotherapy, vol. 31, No. 12, Dec. 1987, pp. 1948-1954
  • The Relationship of Absorption Characteristics and Gastrointestinal Side Effects of Oral Antimicrobial Agents, Grossman, Clinical Therapeutics, vol. 13, No. 1, pp. 189-193 (1991)
  • Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2, Dantzig et al., Biochimica et Biophysica Acta, 1027, pp. 211-217 (1990)
  • Stereochemical Considerations in Drug Absorption, Disposition and Pharmacokinetics, Hutt, Drug Chirality, 24th and 25th Oct. 1990
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  • Angewandte Chemie, vol. 24, No. 3, Mar. 1985, pp. 180-202
  • Pharmacokinetics of FK482, A New Orally Active Cephalosporin, in Animals, Sakamoto et al., The Journal of Antibiotics, vol. XLI, No. 12, pp. 1896-1905 (1988
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