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Gaseous ultrasound contrast media

Patent 5409688 Issued on April 25, 1995. Estimated Expiration Date: Icon_subject June 5, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method of determining pressure within liquid containing vessel
Patent #: 4265251
Issued on: 05/05/1981
Inventor: Tickner

Ultrasonic image enhancement
Patent #: 4276885
Issued on: 07/07/1981
Inventor: Tickner ,   et al.

Microbubble precursors and methods for their production and use
Patent #: 4442843
Issued on: 04/17/1984
Inventor: Rasor ,   et al.

Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium for ultrasonic diagnostics
Patent #: 4466442
Issued on: 08/21/1984
Inventor: Hilmann ,   et al.

Apparatus for forming emulsions
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Issued on: 08/06/1985
Inventor: Cook ,   et al.

Contact agents for ultrasonic imaging
Patent #: 4572203
Issued on: 02/25/1986
Inventor: Feinstein

Microbubble precursors and apparatus for their production and use
Patent #: 4657756
Issued on: 04/14/1987
Inventor: Rasor ,   et al.

Method of production and use of microbubble precursors
Patent #: 4681119
Issued on: 07/21/1987
Inventor: Rasor ,   et al.

Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
Patent #: 4684479
Issued on: 08/04/1987
Inventor: D'Arrigo

Contrast agents for ultrasonic imaging
Patent #: 4718433
Issued on: 01/12/1988
Inventor: Feinstein

More ...

Inventor

Assignee

Application

No. 893657 filed on 06/05/1992

US Classes:

424/9.52, Stable gas bubbles containing or intentional solubilized gas containing424/673, Elemental fluorine or fluorine compound514/743, Halogenated hydrocarbon DOAI514/744, Unsaturated aliphatic compound514/746, Plural halogenated hydrocarbon compounds600/437, Ultrasonic600/458Contrast enhancement

Examiners

Primary: Kumar, Shailendra

Attorney, Agent or Firm

Foreign Patent References

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International Class

A61K 049/00

Abstract

Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of microbubbles comprised of the gas.

Other References

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