U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders

Patent 5405919 Issued on April 11, 1995. Estimated Expiration Date: Icon_subject August 24, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3153094

Gas sensing and measuring device and process using catalytic graphite sensing electrode
Patent #: 4265714
Issued on: 05/05/1981
Inventor: Nolan ,   et al.

Polymeric diffusion matrix containing propranolol
Patent #: 4482533
Issued on: 11/13/1984
Inventor: Keith

Inhibiting polymerization of ethylenically unsaturated monomers
Patent #: 4638079
Issued on: 01/20/1987
Inventor: Inskip ,   et al.

Process for the removal of NO from fluid streams using a water-soluble polymeric chelate of a polyvalent metal
Patent #: 4708854
Issued on: 11/24/1987
Inventor: Grinstead

Nitric oxide abatement with polymeric cobalt(III) chelates
Patent #: 4921683
Issued on: 05/01/1990
Inventor: Bedell

Macrocyclic amine complexes for ligand extraction and generation
Patent #: 4952289
Issued on: 08/28/1990
Inventor: Ciccone, et al.

Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
Patent #: 4954526
Issued on: 09/04/1990
Inventor: Keefer

Radiation curable pressure sensitive adhesive composition
Patent #: 4985471
Issued on: 01/15/1991
Inventor: Ohta, et al.

Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
Patent #: 5039705
Issued on: 08/13/1991
Inventor: Keefer, et al.

More ...

Inventors

Assignee

Application

No. 935565 filed on 08/24/1992

US Classes:

525/377, Nitrogen-containing compound contains at least one nitrile or isonitrile group; or a nitrogen-to-oxygen bond which is other than as an amine or ammonium salt514/611, Nitrosamines (i.e., compounds containing nitroso bonded directly to amino nitrogen)526/311, Nitrogen bonded to oxygen atom (including nitrogen containing salts)528/422NITROGEN-CONTAINING REACTANT

Examiners

Primary: Page, Thurman K.
Assistant: Kulkosky, Peter F.

Attorney, Agent or Firm

Foreign Patent References

  • PCT/US89/02611 EP. 06/13/1989
  • 0425154A1 EP. 10/13/1990
  • 211789 DE. 07/13/1984

International Classes

C08K 005/22
A01N 033/26
A61K 031/785
C08F 008/30

Abstract

A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N2 O2- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is beneficial. The compositions can be used as and/or incorporated into implants, injectables, condoms, prosthesis coatings, patches, and the like for use in a wide variety of medical applications.

Other References

  • Article by Maragos, et al., Complexes of NO with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide. Vasorelaxant Effects, J. Med. Chem., 34, 3242-3247
  • Article by Myers, et al., Vasorelaxant Properties of the Endothelium-Derived Relaxing Factor more closely Resemble S-Nitrosocystein Than Nitric Oxide, Nature, vol. 345
  • Article by Ignarro, Endothelium-Derived Nitric Oxide: Actions and Properties, The FASEB Journal, vol. 3, Jan
  • Article by DeFeudis, Endothelium-Dependent Vasorelaxation--A New Basis for Developing Cardiovascular Drugs, Drugs of Today, vol. 24, No. 2, pp. 103-115
  • Article by Palmer, et al., Nitric Oxide Release Accounts for the Biological Activity of Endothelium-Derived Relaxing Factor, Nature, vol. 327 11, Jun
  • Article by Kruszyna, et al., Red Blood Cells Generate Nitric Oxide from Directly Acting, Nitrogenous Vasodilators, Toxicol. Appl. Pharmacol., 91, 429-438
  • Article by Trissel, Intravenous Infusion Solutions, Handbook on Injectable Drugs, Fourth Addition
  • Article by Furchgott, The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs,Ann. Rev. Pharmacol, Toxicol, 24:175-97
  • Article by DeLuca, et al., Parenteral Drug-Delivery Systems, Pharmaceutics and Pharmacy Practice
  • Article by Hansen, et al., N-Nitrosation of Secondary Amines by Nitric Oxide Via the `Drago Complex`, IARC Sci., Publ. No. 41 pp. 21-29
  • Article by Ignarro, et al., Mechanism of Vascular Smooth Muscle Relaxation by Organic Nitrates, Nitrites, Nitroprusside and Nitric Oxide: Evidence from the Involvement of S-Nitrosothiols as Active Intermediates, J. Pharmacol. Exp. Ther., 218, 739-749
  • Article by Lutz, et al., Isolation of Trioxodinitrato (II) Complexes of Some First Row Transition Metal Ions, J.C.S. Chem. Comm
  • Article by Nakanishi, et al., Participation of Hydrocarbons in the Photodimerization of 3, 4-Dichlorocinnamic Acid, J.C.S. Chem. Comm
  • Article by Longhi, et al., Metal-Containing Compounds of the Anion (C2 H5)2 NN2 O2 --, Insrg. Chem., vol. 2 Feb
  • Article by Drago, Reactions of Nitrogen (II) Oxide, Advances in Chemistry Series, No. 36
  • Article by Drago, et al., The Reaction of Nitrogen (II) Oxide with Various Primary and Secondary Amines, Journal of Amer. Chem. Soc. vol. 83, Apr. 20
  • Article by Garg, et al., Nitric Oxide-Generating Vasodilators Inhibit Mitogenesis and Proliferation of Balb/C3T3 Fibroblasts By A Cyclic GMP-Independent Mechanism, Biochem. and Biophys. Res. Comm., 171, 474-479
  • Article by Hibbs, Jr., et al., Nitric Oxide: A Cytotoxic Activated Macrophage Effector Molecule, Biochem. and Biophys. Res. Comm., 157, 87-94
  • Article by Holford, et al., Understanding the Dose-Effect Relationship: Clinical Application of Pharmacokinetic-Pharmacodynamic Models, Clinical Pharmacokinetics, 6, 429-453
  • Article by Ignarro, Nitric Oxide. A Novel Signal Transduction Mechanism for Transcellular Communication, Hypertension (Dallas), 16, 477-483
  • Article by Ignarro, Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide, Annu. Rev. Pharmcol. Toxicol., 30, 535-560
  • Article by Ignarro, et al., The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation, Annu. Rev. Pharmacol. Toxicol., 25, 171-191
  • Article by Kuhn, et al., Endothelium-Dependent Vasodilatation in Human Epicardial Coronary Arteries: Effect of Prolonged Exposure to Glycerol Trinitrate or SIN-1, J. Cardiovasc. Pharmacol., 14 (Suppl. 11), S47-S54
  • Marletta, et al., Unraveling the Biological Significance of Nitric Oxide, BioFactors, 2, 219-225
  • Smith, et al., Nitroprusside: A Potpourri of Biologically Reactive Intermediates, Biological Reactive Intermediates IV. Molecular and Cellular Effects and Their Impact on Human Health (Witmer, et al., eds.), Advances in Experimental Medicine and Biology, vol. 283 (Plenum Press, pp. 365-369)
  • Stuehr, et al., Nitric Oxide: A Macrophage Product Responsible for Cytostasis and Respiratory Inhibition in Tumor Target Cells, J. Exp. Med., 169, 1543-1555
  • WHO Task Group on Environmental Health Criteria for Oxides of Nitrogen, Oxides of Nitrogen, Environmental Health Criteria 4 (World Health Organization: Geneva)
  • Article by Wilcox, et al., Effect of Cyanide on the Reaction of Nitroprusside with Hemoglobin: Relevance to Cyanide Interference With the Biological Activity of Nitroprusside, Chem. Res. Toxicol., 3, 71-76
  • Article by Stamler, et al., S-Nitrosylation of Proteins With Nitric Oxide: Synthesis and Characterization of Biologically Active Compounds, Proc. Natl. Acad. Sci., USA, vol. 89, pp. 444-448, Jan
  • Article by Smith, et al., Complex Contractile Patterns in Canine Colon Produced by Spontaneous Release of Nitric Oxide, Gastroenterology, vol. 102, No. 4 Part 2, Apr
  • Article by Jones, Metastable Polymers of the Nitrogen Oxides. 1. Open Chain Nitric Oxide Analogues of Polythlazyl: A MNDO/AM1 Study, J. Phys. Chem., 95, 2588-2595
  • Article by Middleton, et al., Further Studies on the Interaction of Nitric Oxide With Transition-Metal Alkyls, J.C.S. Dalton, pp. 1898-1905, Feb. 6
  • Article by Bonakdar, et al., Continuous-Flow Performance of Carbon Electrodes Modified With Immobilized Fe(II)/Fe(III) Centers, Calanta, vol. 36, No. 1/2, pp. 219-225
  • Article by Park, et al., Controlled Protein Release from Polyethyleneimine-Coated Poly (L-lactic Acid)/Pluronic Blend Matrices, Pharmaceutical Research, vol. 9, No. 1
  • Uber Reaktionen und Eigenschaften des Stickoxyds und seiner Verbindungen, II. Mitteil: Zur Kenntnis der Salze Der stickoxyd-schwefligen Saure, Heinz Gehlen, Aus D. Chem. Institut D. Universitat Konigsberg I. PR., Eingegaugen am 1. Juni
  • Der Raman-Effekt als Grundlage einer organischen Spektralanalyse (I. Mitteil.), Birchkenbach, et al., Aus D. Chem. Institut D. Betgakademie Clausthal, Eingegaugen am 9, Juni
  • Synthesis of 1-Alkoxy-3,3-Dialkyltriazene 2-Oxides from Alkoxyamines and Nitrosoamines, Artsybasheva, et al., A. A. Zhdanov Leningrad State University, Translated from Zhurhal Organicheskoi Khimii, vol. 28, No. 6, pp. 1168-1173, Jun., Original article submitted May 28, 1986
  • Jones, "Metastable Polymers of the Nitrogen Oxides. 2. Open-Chain Polymers of the Nitric Oxide Dimers and of Nitrous Oxide: A MNDO/AM1 Study," J. Phys. Chem., 96, 594-603 (1992
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
PatentsPlus: add to cart
PatentsPlus: add to cartIntelligent turbocharged patent PDFs with marked up images
$16.95more info
 
Sign InRegister
Username  
Password   
forgot password?