Aliphatic or fatty acid esters as a solventless carrier for pharmaceuticals
Patent 5405617 Issued on April 11, 1995. Estimated Expiration Date: 
April 11, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 11, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2011586 Increasing the absorption rate of insoluble drugs Analgesic and anti-inflammatory compositions for topical application Urea derivatives Pharmaceutical composition Method for the preparation of coated solid medicament form Compounds and compositions having anti-inflammatory and analgesic activity Patent #: 5013759 InventorsAssigneeApplicationNo. 790613 filed on 11/07/1991US Classes:424/464, Tablets, lozenges, or pills424/484, Matrices424/485, Natural gums, resin or latex424/496, Containing natural gums/resins424/502Contains waxes, higher fatty acids, higher fatty alcoholsExaminersPrimary: Page, Thurman K.Assistant: Levy, Neil S. Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/16AbstractA physicochemically stable pharmaceutical matrix composition is provided comprising: a pharmaceutical active and a water insoluble aliphatic or fatty acid ester, preferably stearyl stearate; a taste mask carrier for pharmaceutical actives comprising a taste masking effective amount of an aliphatic or fatty acid ester; and a method for preparing a pharmaceutical matrix without the use of organic and/or volatile solvents comprising the steps of: melting an aliphatic or fatty acid ester; admixing at least one pharmaceutical active with the molten aliphatic or fatty acid ester; and solidifying the admixture to produce a pharmaceutical matrix composition. The matrix is composed of an aliphatic, or fatty acid, ester that has a low melting point (50°-100° C.) and the melt exhibits: low viscosity, recongeals rapidly when cooled, does not exhibit polymorphism, and has good mold release properties.Other References
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