U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Acyl compounds

Patent 5399578 Issued on March 21, 1995. Estimated Expiration Date: Icon_subject December 29, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds used as anti-hypertensive agents
Patent #: 4333943
Issued on: 06/08/1982
Inventor: Kurchacova ,   et al.

Process for making phenylthiopyrimidines
Patent #: 4748245
Issued on: 05/31/1988
Inventor: James

Imidazolyl or tetrazolyl substituted benzoic acid derivatives and pharmaceutical compositions thereof
Patent #: 4755518
Issued on: 07/05/1988
Inventor: Rafferty ,   et al.

Angiotensin II receptor blocking tertiary amides Patent #: 5260325
Issued on: 11/09/1993
Inventor: Markwalder, et al.

Inventors

Assignee

Application

No. 998755 filed on 12/29/1992

US Classes:

514/381, Tetrazoles (including hydrogenated)548/253The chalcogen, X, is in a -C(=X)- group

Examiners

Primary: Springer, David B.

Attorney, Agent or Firm

Foreign Patent References

  • 2014008 CA. 10/13/1990
  • 0148752 EP. 07/13/1985
  • 0324377 EP. 08/13/1985
  • 9114679 WO. 10/13/1991

International Classes

C07D 257/04
A61K 031/41

Foreign Application Priority Data

1990-02-19 CH

Abstract

Compounds of the formula ##STR1## in which R1 is an aliphatic hydrocarbon radical which is unsubstituted or substituted by halogen or hydroxyl, or a cycloaliphatic or araliphatic hydrocarbon radical; X1 is CO, SO2, or --O--C(=O)-- with the carbon atom of the carbonyl group being attached to the nitrogen atom shown in formula I; X2 is a divalent aliphatic hydrocarbon radical which is unsubstituted or substituted by hydroxyl, carboxyl, amino, guanidino or a cycloaliphatic or aromatic radical, or is a divalent cycloaliphatic hydrocarbon radical, it being possible for a carbon atom of the aliphatic hydrocarbon radical to be additionally bridged by a divalent aliphatic hydrocarbon radical; R2 is carboxyl which, if desired, is esterified or amidated, substituted or unsubstituted amino, formyl which, if desired, is acetalized, 1H-tetrazol-5-yl, pyridyl, hydroxyl which, if desired, is etherified, S(O)m --R where m is 0, 1 or 2 and R is hydrogen or an aliphatic hydrocarbon radical, alkanoyl, unsubstituted or N-substituted sulfamoyl or POn H2 where n is 2 or 3; X3 is a divalent aliphatic hydrocarbon; R3 is carboxyl, 5-tetrazolyl, SO3 H, PO2 H2, PO3 H2 or haloalkylsulfamoyl; and the rings A and B independently of one another are substituted or unsubstituted; in free form or in salt form, can be prepared in a manner known per se and can be used, for example, as medicament active ingredients.

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