Patent ReferencesEthyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds used as anti-hypertensive agents Process for making phenylthiopyrimidines Imidazolyl or tetrazolyl substituted benzoic acid derivatives and pharmaceutical compositions thereof Angiotensin II receptor blocking tertiary amides Patent #: 5260325 InventorsAssigneeApplicationNo. 998755 filed on 12/29/1992US Classes:514/381, Tetrazoles (including hydrogenated)548/253The chalcogen, X, is in a -C(=X)- groupExaminersPrimary: Springer, David B.Attorney, Agent or FirmForeign Patent References
International ClassesC07D 257/04A61K 031/41 Foreign Application Priority Data1990-02-19 CHAbstractCompounds of the formula ##STR1## in which R1 is an aliphatic hydrocarbon radical which is unsubstituted or substituted by halogen or hydroxyl, or a cycloaliphatic or araliphatic hydrocarbon radical; X1 is CO, SO2, or --O--C(=O)-- with the carbon atom of the carbonyl group being attached to the nitrogen atom shown in formula I; X2 is a divalent aliphatic hydrocarbon radical which is unsubstituted or substituted by hydroxyl, carboxyl, amino, guanidino or a cycloaliphatic or aromatic radical, or is a divalent cycloaliphatic hydrocarbon radical, it being possible for a carbon atom of the aliphatic hydrocarbon radical to be additionally bridged by a divalent aliphatic hydrocarbon radical; R2 is carboxyl which, if desired, is esterified or amidated, substituted or unsubstituted amino, formyl which, if desired, is acetalized, 1H-tetrazol-5-yl, pyridyl, hydroxyl which, if desired, is etherified, S(O)m --R where m is 0, 1 or 2 and R is hydrogen or an aliphatic hydrocarbon radical, alkanoyl, unsubstituted or N-substituted sulfamoyl or POn H2 where n is 2 or 3; X3 is a divalent aliphatic hydrocarbon; R3 is carboxyl, 5-tetrazolyl, SO3 H, PO2 H2, PO3 H2 or haloalkylsulfamoyl; and the rings A and B independently of one another are substituted or unsubstituted; in free form or in salt form, can be prepared in a manner known per se and can be used, for example, as medicament active ingredients. |
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