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US Patent 5395628 - Controlled release succinic acid microcapsules coated with aqueous acrylics

US Patent Issued on March 7, 1995
Estimated Patent Expiration Date: Icon_subject April 13, 2012Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

A controlled release pharmaceutical preparation comprising (a) a core containing a pharmaceutically active substance and an organic acid, and (b) a coating film formed on the surface of the core by aqueous coating of a water-insoluble and water-slightly permeable acrylic polymer containing a trimethylammonium-ethyl group, which exhibits well controlled dissolution and release of the pharmaceutically active substance when administered and can maintain the desired blood level of the active substance for a long period of time, and a method for producing the preparation.

Other References

  • Documentation from Rohm Pharma, "EUDRAGIT.RTM. RL/RS-Dispersionen"; Vorlaufiges Merkblatt
  • Documentation from Rohm Pharma GmbH Co., "Eudragit RL30D and RS30D: Aqueous Acrylic Resin Dispersion-Application in the Production of Pharmaceutical Preparations", Prospectus (Infor RL/RSD-1/e), pp. 1-7
  • R. S. Okor, W. Anderson, "Communications: Casting solvent effects on the permeability of polymer films of differing quaternary ammonium (cation) content", J. Pharm. Pharmacol, (1987) 39, pp. 547-54

Inventors

Assignee

Application

No. 870195 filed on 04/13/1992

US Classes:

424/490, Coated (e.g., microcapsules)424/468, Sustained or differential release type424/474, Coated pills or tablets424/487Acrylic acid and derivatives

Field of Search

424/464, Tablets, lozenges, or pills424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/468, Sustained or differential release type424/477, Containing proteins or derivatives thereof424/482, Containing solid synthetic polymers424/490Coated (e.g., microcapsules)

Examiners

Primary: Page, Thurman K.
Assistant: Levy, Neil S.

Attorney, Agent or Firm

US Patent References

4427648, Dipyridamole-containing pharmaceutical form
Issued on: 01/24/1984
Inventor: Brickl ,   et al.
4737357, Aqueous coating dispersions
Issued on: 04/12/1988
Inventor: Lehmann ,   et al.
4820521, Sustained absorption pharmaceutical composition
Issued on: 04/11/1989
Inventor: Panoz ,   et al.
4940588Controlled release powder and process for its preparation
Issued on: 07/10/1990
Inventor: Sparks, et al.

Foreign Patent References

  • 0122077 EP. 10/15/1984
  • 0156077 EP. 10/15/1985
  • 0156243 EP. 10/15/1985
  • 0181515 EP. 05/15/1986
  • 0225085 EP. 06/15/1987
  • 0262422 EP. 08/15/1987
  • 88/03795 WO. 06/15/1988

International Class

A61K 009/50

Foreign Application Priority Data

1989-12-28 JP

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