Process for the preparation of a pharmaceutical formulation containing at least two different active substances and use of such a formulation

Patent 5393531 Issued on February 28, 1995. Estimated Expiration Date:

July 1, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Inventors

Application

No. 907481 filed on 07/01/1992

US Classes:

424/466, Effervescent424/43, EFFERVESCENT OR PRESSURIZED FLUID CONTAINING424/480Cellulose or derivative

Examiners

Primary: Page, Thurman K.
Assistant: Benston, William E. Jr.

Attorney, Agent or Firm

Ostrolenk, Faber, Gerb & Soffen

International Class

A61K 009/96

Foreign Application Priority Data

1991-07-01 CH

Abstract

An aqueous solution or dispersion for oral intake of at least two different pharmaceutical active substances is prepared by dissolving or suspending at least two different effervescent, soluble and/or disintegrating mixtures in tablet or granule form, each of which contains a different active substance or a different active substance combination, in one and the same quantity of water. At least one of the tablets may be used only as a fragment, and at least one of the mixtures may weigh less than 2000 mg, preferably less than 1500 mg, in particular less than 1000 mg. In particular at least one of the mixtures contains diuretic, in particular hydrochlorothiazide and/or furosemide, and at least one of the further mixtures contains a beta-blocker and/or a vasodilator, in particular naftidrofuryl, calcium antagonist, ACE inhibitor or alpha-1-blocker. Such effervescent, soluble and/or disintegrating mixtures in tablet or granule form are preferably used for the treatment of hypertension. Other active substance combinations are suitable for the treatment of asthma or osteoporosis or for ulcer therapy.