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...During the Civil War, the Confederacy established its own Patent Office which issued 266 patents, a third of which concerned implements of war.
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US Patent 5393531 - Process for the preparation of a pharmaceutical formulation containing at least two different active substances and use of such a formulation
US Patent Issued on February 28, 1995
Estimated Patent Expiration Date:
July 1, 2012Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
July 1, 2012Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractAn aqueous solution or dispersion for oral intake of at least two different pharmaceutical active substances is prepared by dissolving or suspending at least two different effervescent, soluble and/or disintegrating mixtures in tablet or granule form, each of which contains a different active substance or a different active substance combination, in one and the same quantity of water. At least one of the tablets may be used only as a fragment, and at least one of the mixtures may weigh less than 2000 mg, preferably less than 1500 mg, in particular less than 1000 mg. In particular at least one of the mixtures contains diuretic, in particular hydrochlorothiazide and/or furosemide, and at least one of the further mixtures contains a beta-blocker and/or a vasodilator, in particular naftidrofuryl, calcium antagonist, ACE inhibitor or alpha-1-blocker. Such effervescent, soluble and/or disintegrating mixtures in tablet or granule form are preferably used for the treatment of hypertension. Other active substance combinations are suitable for the treatment of asthma or osteoporosis or for ulcer therapy. | InventorsApplicationNo. 907481 filed on 07/01/1992US Classes:424/466, Effervescent424/43, EFFERVESCENT OR PRESSURIZED FLUID CONTAINING424/480Cellulose or derivativeField of Search424/466, Effervescent424/482, Containing solid synthetic polymers424/440, Candy, candy coated or chewing gum424/43EFFERVESCENT OR PRESSURIZED FLUID CONTAININGExaminersPrimary: Page, Thurman K.Assistant: Benston, William E. Jr. Attorney, Agent or FirmUS Patent References3906107, 4289751, Effervescent enteric-coated formulation of soluble form of erythromycin and therapeutic use thereofIssued on: 09/15/1981 Inventor: Windheuser4684516, Sustained release tablets and method of making same Issued on: 08/04/1987 Inventor: Bhutani4832956, Disintegrating tablet and process for its preparation Issued on: 05/23/1989 Inventor: Gergely , et al.4865849, Tablet for pharmaceutical use able to release active substances at successive times Issued on: 09/12/1989 Inventor: Conte , et al.4940588, Controlled release powder and process for its preparation Issued on: 07/10/1990 Inventor: Sparks, et al.5073377, Method of preparing oral dosage forms with a granulating composition Issued on: 12/17/1991 Inventor: Alexander, et al.5126348Bioavailability enhancers Issued on: 06/30/1992 Inventor: McMurray International ClassA61K 009/96Foreign Application Priority Data1991-07-01 CH |
