U.S. patents available from 1976 to present.
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Solid care therapeutic compositions and methods for making same

Patent 5389377 Issued on February 14, 1995. Estimated Expiration Date: Icon_subject October 7, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Magnetically-localizable, biodegradable lipid microspheres
Patent #: 4331654
Issued on: 05/25/1982
Inventor: Morris

Method of magnetic resonance imaging of the liver and spleen
Patent #: 4675173
Issued on: 06/23/1987
Inventor: Widder

Preparation of solid core liposomes
Patent #: 4839111
Issued on: 06/13/1989
Inventor: Huang

Method for preparing magnetic powder
Patent #: 4945049
Issued on: 07/31/1990
Inventor: Hamaya, et al.

Method for producing magnetic microparticles from metallocenes
Patent #: 5071076
Issued on: 12/10/1991
Inventor: Chagnon, et al.

Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs Patent #: 5091187
Issued on: 02/25/1992
Inventor: Haynes

Inventors

Assignee

Application

No. 958646 filed on 10/07/1992

US Classes:

424/450, Liposomes424/490, Coated (e.g., microcapsules)424/498, Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof424/600, INORGANIC ACTIVE INGREDIENT CONTAINING424/617, Heavy metal or compound thereof424/630, Copper424/635, Oxide424/639, Manganese424/641, Zinc424/644, Mercury424/646, Iron, cobalt, nickel, vanadium, molybdenum, or palladium424/650, Tin, gallium, germanium, indium, or tellurium428/402.24Microcapsule with solid core (includes liposome)

Examiners

Primary: Kishore, G. S.

Attorney, Agent or Firm

Foreign Patent References

  • 0125995 EP 11/13/1984
  • 0546939 EP 06/13/1993
  • 8911335 WO 11/13/1989
  • 9109678 WO 07/13/1991

International Class

A61K 009/127

Abstract

A liposome composition which comprises a substantially uniform sized inorganic core coated with an amphipathic organic compound and further coated with a second amphipathic vesicle forming lipid. Also disclosed are novel phenyl lipid compounds which serve as the amphipathic vesicle forming lipid and methods are described for delivering a drug for slow release into the blood stream, and for targeting a selected tissue or cells with the inorganic core liposome compositions.

Other References

  • Chan et al, "Magnetic Resonance Imaging of Abscesses Using Lipid-Coated Iron Oxide Parties", pp. 443-449, Jun. 1992
  • Dinger et al, "Safety Profile of Gd-DTPA: Clinical Experience", Berlin, West Germany, Abstract only, Nov. 1990
  • Tzika et al, "Ferrosomes: Long-lived Superparamagnetic MR Imaging Contrast Agent", San Francisco, Calif., Abstract, Nov. 1990
  • Reimer et al, "Improved Detection of Liver Cancer with Hepatocyte-directed superparamagnetic Iron Oxide Particles" Charlestown, Mass., Abstract only, Nov. 1990
  • Chan, et al, "MR Imaging of Abscess by Use of Lipid-coated Iron Oxide Particles", Philadelphia, Pa., Abstract only, Nov. 199
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