U.S. patents available from 1976 to present.
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Aerosol delivery article

Patent 5388574 Issued on February 14, 1995. Estimated Expiration Date: Icon_subject July 29, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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1968509

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Inventor

Application

No. 099015 filed on 07/29/1993

US Classes:

128/203.17, Electrically heated means producing water vapor128/200.16, Ultrasonic128/203.26Means for heating treating agent, respiratory gas, or mixture thereof

Examiners

Primary: Burr, Edgar S.
Assistant: Raciti, Eric P.

International Classes

A61M 015/00
203.16
203.17
203.26

Abstract

An aerosol delivery article provides delivery of aerosol particles of relatively small size without the necessity of exposing the material which is aerosolized to a significant degree of heat or high temperatures. An aerosol forming material is a multi-component material comprising an active ingredient and another ingredient having a relatively low vaporization temperature, and preferably that aerosol forming material is in the form of an emulsion. The aerosol forming material is nebulized so as to provide first stage multi-component aerosol particles of fairly large size. The first stage aerosol particles then are subjected to heat so as to vaporize the other ingredient of that aerosol and cause further dispersion of that first stage aerosol. As such, a second stage aerosol composed of fine particles of active ingredient is provided. The heat used to cause the further dispersion of the first stage aerosol is less than that sufficient to cause vaporization, thermal decomposition or undesirable chemical alteration of the active ingredient.

Other References

  • Paul C. Hiemenz; Principles of Colloid and Surface Chemistry; 1986; pp. 467-474
  • Anthony J. Hickey; Summary of Common Approaches to Pharmaceutical Aerosol Administration; (1992); 255-288
  • Giuseppe Tarroni, et al; An Indication on the Biological Variability of Aerosol Total Deposition in Humans; Am. Ind. Hyg. Assoc. J.; 41; Nov. 1980; pp. 826-831
  • Richard N. Berglung, et al; Generation of Monodisperse Aerosol Standards; Environ Sci Technol vol. 7, No. 2, Feb., 1973; pp. 147-153
  • M. J. Fulwyler; Electronic Separation of Biological Cells by Volume; Science, vol. 150; 1965; pp. 910-911
  • Lars Strom; The Generation of Monodisperse Aerosols by Means of a Disintergrated Jet of Liquid; The Review of Scientific Instruments; vol. 40, No. 6; Jun., 1969; pp. 778-782
  • Vittorio Prodi, A Condensation Aerosol Generator for Solid Monodisperse Particles; Assessment of Airborne Particles Fundamentals Applications and Implications to Inhalation Toxicity; 1972; pp. 169-181
  • C. N. Davies; Generation and use of Monodisperse Aerosols; Aerosol Science; 1966; pp. 1-3
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