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US Patent 5388574 - Aerosol delivery article

US Patent Issued on February 14, 1995
Estimated Patent Expiration Date: Icon_subject July 29, 2013Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

An aerosol delivery article provides delivery of aerosol particles of relatively small size without the necessity of exposing the material which is aerosolized to a significant degree of heat or high temperatures. An aerosol forming material is a multi-component material comprising an active ingredient and another ingredient having a relatively low vaporization temperature, and preferably that aerosol forming material is in the form of an emulsion. The aerosol forming material is nebulized so as to provide first stage multi-component aerosol particles of fairly large size. The first stage aerosol particles then are subjected to heat so as to vaporize the other ingredient of that aerosol and cause further dispersion of that first stage aerosol. As such, a second stage aerosol composed of fine particles of active ingredient is provided. The heat used to cause the further dispersion of the first stage aerosol is less than that sufficient to cause vaporization, thermal decomposition or undesirable chemical alteration of the active ingredient.

Other References

  • Paul C. Hiemenz; Principles of Colloid and Surface Chemistry; 1986; pp. 467-474
  • Anthony J. Hickey; Summary of Common Approaches to Pharmaceutical Aerosol Administration; (1992); 255-288
  • Giuseppe Tarroni, et al; An Indication on the Biological Variability of Aerosol Total Deposition in Humans; Am. Ind. Hyg. Assoc. J.; 41; Nov. 1980; pp. 826-831
  • Richard N. Berglung, et al; Generation of Monodisperse Aerosol Standards; Environ Sci Technol vol. 7, No. 2, Feb., 1973; pp. 147-153
  • M. J. Fulwyler; Electronic Separation of Biological Cells by Volume; Science, vol. 150; 1965; pp. 910-911
  • Lars Strom; The Generation of Monodisperse Aerosols by Means of a Disintergrated Jet of Liquid; The Review of Scientific Instruments; vol. 40, No. 6; Jun., 1969; pp. 778-782
  • Vittorio Prodi, A Condensation Aerosol Generator for Solid Monodisperse Particles; Assessment of Airborne Particles Fundamentals Applications and Implications to Inhalation Toxicity; 1972; pp. 169-181
  • C. N. Davies; Generation and use of Monodisperse Aerosols; Aerosol Science; 1966; pp. 1-3

Inventor

Application

No. 099015 filed on 07/29/1993

US Classes:

128/203.17, Electrically heated means producing water vapor128/200.16, Ultrasonic128/203.26Means for heating treating agent, respiratory gas, or mixture thereof

Field of Search

128/200.14, LIQUID MEDICAMENT ATOMIZER OR SPRAYER128/200.15, With tongue depressor128/200.16, Ultrasonic128/200.17, Rotating128/200.18, Spray impinged against baffle in or adjacent flow conduit128/200.19, Means for selectively dispensing different fluids128/200.21, Gas stream aspirating medicament from reservoir128/200.22, Gas flow induced by expansion chamber device (e.g., piston/cylinder ram, squeeze bulb, etc.)128/200.23Pre-pressurized container holding medicament

Examiners

Primary: Burr, Edgar S.
Assistant: Raciti, Eric P.

US Patent References

1771366, 1968509, 2030075, 2057353, 2248591, 2332799, 2764154, 3297029, 3820540, 3859398, 3864544, 3990441, Nebulizer heater
Issued on: 11/09/1976
Inventor: Hoyt ,   et al.
4036224, Portable conditioned air breathing pipe
Issued on: 07/19/1977
Inventor: Choporis ,   et al.
4190046, Nebulizer cap system having heating means
Issued on: 02/26/1980
Inventor: Virag
4214146, Electrically heated vaporizer device for dispensing a thermally volatilizable substance
Issued on: 07/22/1980
Inventor: Schimanski
4303083, Device for evaporation and inhalation of volatile compounds and medications
Issued on: 12/01/1981
Inventor: Burruss, Jr.
4523589, Method and apparatus for treating ailments
Issued on: 06/18/1985
Inventor: Krauser
4655229, Flavor delivery system
Issued on: 04/07/1987
Inventor: Sensabaugh, Jr. ,   et al.
4655959, Preparation of non-flammable aerosol propellant microemulsion system
Issued on: 04/07/1987
Inventor: Stopper
4715387, Aerosol for use in the reduction of tobacco smoking
Issued on: 12/29/1987
Inventor: Rose
4735217, Dosing device to provide vaporized medicament to the lungs as a fine aerosol
Issued on: 04/05/1988
Inventor: Gerth ,   et al.
4765347, Aerosol flavor delivery system
Issued on: 08/23/1988
Inventor: Sensabaugh, Jr. ,   et al.
4832012, Intermittent signal actuated nebulizer
Issued on: 05/23/1989
Inventor: Raabe ,   et al.
4922901, Drug delivery articles utilizing electrical energy
Issued on: 05/08/1990
Inventor: Brooks, et al.
4941482, Apparatus for measuring the density of a tobacco stream
Issued on: 07/17/1990
Inventor: Heitmann, et al.
4951659, Nebulizer with cooperating disengageable on-line heater
Issued on: 08/28/1990
Inventor: Weiler, et al.
4963367, Drug delivery compositions and methods
Issued on: 10/16/1990
Inventor: Ecanow
5145604Aqueous emulsion and aerosol delivery system using same
Issued on: 09/08/1992
Inventor: Neumiller

International Classes

A61M 015/00
203.16
203.17
203.26

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