Compositions containing corticosteroids or analogues thereof and corticosteroid buffering effective amounts of 5-androstene 3B, 17B or 5-androstene 3B, 7B, 17B triol or analogues thereof
Patent 5387583 Issued on February 7, 1995. Estimated Expiration Date: 
April 20, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 20, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorApplicationNo. 050579 filed on 04/20/1993US Classes:514/171, With additional active ingredient424/93.71, Leukocyte514/178, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/182, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system552/634, Carbon or halogen bonded directly at the 1- or 3-position552/636Unsaturation between the 5- and 6-positions (e.g., dehydroandrosterones, etc.)ExaminersPrimary: Dees, Jose G.Assistant: Jones, Dwayne C. Attorney, Agent or FirmInternational ClassA61K 031/565Abstract3ଲ,17ଲ-androstenediol ("�") and 3ଲ,7ଲ,17ଲ-androstenetriol ("T") may be used to counteract the antiproliferative and immunosuppressive effects of hydrocortisone and other corticosteroids (i.e., to act as buffers to counteract the lymphosuppressive response to such steroids). � and T are steroids which mediate immune response to provide the body protection against immune down-regulation. A method for testing analogues of � and T to compare the effectiveness of such analogues as buffers of certain effects of hydrocortisone and other corticosteroids, including immune response and proliferative effects is described. Cytokines, including most particularly IL-3, are produced by addition of T and � and their analogues to the growth media of cell cultures of lymphatic cells.Field of SearchWith additional active ingredientOxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system Carbon or halogen bonded directly at the 1- or 3-position Unsaturation between the 5- and 6-positions (e.g., dehydroandrosterones, etc.) |
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