System for controlled release of antiarrhythmic agents
March 26, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesSystem with microporous releasing diffusor Polymeric article for dispensing drugs Bioadhesive compositions and methods of treatment therewith Cardiovascular prosthetic devices and implants with porous systems Controlled drug delivery system for treatment of neural disorders Delivery systems for the controlled administration of LHRH analogs Implant drug delivery device Patent #: 5141748 InventorsApplicationNo. 037810 filed on 03/26/1993US Classes:424/422, Implant or insert424/423, Surgical implant or material424/424, Membrane or diffusion barrier424/425, Diffusion barrier is matrix514/821, ANTIARRHYTHMIC604/891.1, Implanted dynamic device or system607/120, With drug or medicament-dispensing607/129Patch or epicardial (on heart surface) typeExaminersPrimary: Page, Thurman K.Assistant: Hulina, Amy Attorney, Agent or FirmInternational ClassA61K 009/00AbstractA system for controlled release, site-specific delivery of therapeutic agents, particularly myocardial agents such as antiarrhythmic agents, comprises a biocompatible polymeric matrix with an incorporated therapeutic agent for direct placement at the epicardium. Advantageously, the dosage form can be fabricated in such a manner as to tailor the release characteristics as required by the nature of the physical condition desired to be treated. In a specific illustrative embodiment, lidocaine, an antiarrhythmic depressant, is incorporated in polyurethane by a unique method which permits drug-loading of the polymeric matrix from about 5% up to 40% by weight, with about 25% to 30% in a preferred embodiment. A novel FeCl3 catalyst causes the polyurethane to polymerize despite the presence of drug in the polymeric matrix mixture. | |
