Method of treating abnormal concentrations of TNF
Patent 5385901 Issued on January 31, 1995. Estimated Expiration Date: 
October 2, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
October 2, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References2830991 InventorsApplicationNo. 955936 filed on 10/02/1992US Classes:514/231.5, Additional hetero ring attached directly or indirectly to the morpholine ring by nonionic bonding514/231.2, Morpholines (i.e., fully hydrogenated 1,4- oxazines)514/282, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)514/327, Chalcogen bonded directly to ring carbon of the piperidine ring514/331, Nitrogen attached indirectly to the piperidine ring by nonionic bonding514/348Chalcogens bonded directly to at least two ring carbons of the six-membered hetero ringExaminersPrimary: Henley, III, RaymondAssistant: Criares, T. J. Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/535A61K 031/44 A61K 031/445 AbstractCompounds of the structure ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl radicals of 1-6 carbon atoms, the phenyl radical, and the benzyl radical; and wherein R' is selected from the group consisting of the phthalimido radical and the succinimido radical and of the structure ##STR2## wherein X is CH2 or C=O; R" is H, --CH2 CH3, --C6 H5, --CH2 C6 H5, --CH2 CH=CH2, or ##STR3## and hydrolysis products of said compounds wherein R" is H and the piperidino ring or both the piperidino and the imido ring are hydrolyzed are useful for the control of abnormal concentrations of TNF manifested in septic shock, cachexia and HIV infection without substantially effecting the concentration of other cytokines.Other References
Field of SearchChalcogen bonded directly to ring carbon of the piperidine ringChalcogens bonded directly to at least two ring carbons of the six-membered hetero ring One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.) Morpholines (i.e., fully hydrogenated 1,4- oxazines) Additional hetero ring attached directly or indirectly to the morpholine ring by nonionic bonding Nitrogen attached indirectly to the piperidine ring by nonionic bonding | |
