Biodegradable magnetic microclusters and methods for making them

Patent 5382468 Issued on January 17, 1995. Estimated Expiration Date:

December 22, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Coated magnetizable microparticles, reversible suspensions thereof, and processes relating thereto
Patent #: 4454234
Issued on: 06/12/1984
Inventor: Czerlinski

Method of magnetic resonance imaging of the liver and spleen
Patent #: 4675173
Issued on: 06/23/1987
Inventor: Widder

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Patent #: 4795698
Issued on: 01/03/1989
Inventor: Owen , et al.

Superparamagnetic liquid colloids
Patent #: 5147573
Issued on: 09/15/1992
Inventor: Chagnon

Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement Patent #: 5213788
Issued on: 05/25/1993
Inventor: Ranney

Inventors

Assignee

Molecular Bioquest, Inc.

Application

No. 995070 filed on 12/22/1992

US Classes:

428/328, Heavy metal or aluminum or compound thereof428/332, Physical dimension specified428/402.24, Microcapsule with solid core (includes liposome)428/407, Including synthetic resin or polymer428/900, MAGNETIC FEATURE436/173NUCLEAR MAGNETIC RESONANCE, ELECTRON SPIN RESONANCE OR OTHER SPIN EFFECTS OR MASS SPECTROMETRY

Examiners

Primary: Resan, Stevan A.

Attorney, Agent or Firm

Hayes, Soloway, Hennessey, Grossman & Hage

Foreign Patent References

WO8702063 WO 04/13/1987
WO9109678 WO 07/13/1991
WO9115243 WO 10/13/1991
WO9202940 WO 02/13/1992
WO9204916 WO 04/13/1992

International Class

B32B 027/02

Abstract

Subdomain metal or metal oxide particles covalently coupled to chemically reactive organic moieties and subsequently reacted together to form biodegradable magnetic microclusters are disclosed. The magnetic microcluster can be used as contrast agents in NMR imaging for the production of images suitable for use in diagnosis, for in vivo delivery and targeting of drugs, as in vivo, biodegradable agents for the sequestering of free metal ions in the treatment of metal driven disease.

Other References

J. Appl. Phys. vol. 41, No. 3, Mar. 1970, pp. 1064-1072 R. Kaiser et al "Magnetic Properties of Stable Dispersions of Subdomain Magnetite Particles"
Invest Radiol. vol. 27, No. 6, Jun. 1992, pp. 450-455 A. Iannone "Detection and Quantification in Rat Tissues of Magnetite as Demonstrated by Electron Spin Resonance Spectroscopy