Transdermal administration of short or intermediate half-life benzodiazepines
Patent 5378473 Issued on January 3, 1995. Estimated Expiration Date: 
June 28, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 28, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one Skin permeation enhancer compositions Transdermal administration of short or intermediate half-life benzodiazepines Patent #: 5225198 InventorsAssigneeApplicationNo. 083676 filed on 06/28/1993US Classes:424/449, Transdermal or percutaneous424/447, Bandages with incorporated medicaments424/448Pressure sensitive adhesive meansExaminersPrimary: Phelan, D. GabrielleAttorney, Agent or FirmForeign Patent References
International ClassA61F 013/00AbstractMethod and laminated composite for administering short or intermediate half-life benzodiazepines such as alprazolam or triazolam transdermally to treat conditions such as anxiety in the case of alprazolam and insomnia in the case of triazolam. The composite comprises an impermeable backing layer and a reservoir layer containing the benzodiazepine and a permeation enhancer combined with a solvent-based acrylic polymer adhesive with the amounts of benzodiazepine and enhancer being sufficient to cause the benzodiazepine to pass through the skin at a rate in excess of about one μg/cm2 /hr.Other References
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