Patent References
1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocines Patent #: 4105659 Issued on: 08/08/1978 Inventor: Archer Analgesic compositions Patent #: 4582835 Issued on: 04/15/1986 Inventor: Lewis , et al. Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists Patent #: 4668685 Issued on: 05/26/1987 Inventor: Shami Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration Patent #: 4673679 Issued on: 06/16/1987 Inventor: Aungst , et al. N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes Patent #: 4722928 Issued on: 02/02/1988 Inventor: Boswell , et al. Inducing analgesia by implantation of cells releasing neuroactive substances Patent #: 4753635 Issued on: 06/28/1988 Inventor: Sagen , et al. Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists Patent #: 4760069 Issued on: 07/26/1988 Inventor: Rzeszotarski , et al. Method of treating patients suffering from chronic pain or chronic cough Patent #: 4769372 Issued on: 09/06/1988 Inventor: Kreek Method of treating patients suffering from chronic pain or chronic cough Patent #: 4785000 Issued on: 11/15/1988 Inventor: Kreek , et al. Method of treatment for autoimmune diseases Patent #: 4857533 Issued on: 08/15/1989 Inventor: Sherman , et al. More ... Method of treatment for arthritic and inflammatory diseases Patent #: 4863928 Issued on: 09/05/1989 Inventor: Atkinson , et al. Method for the treatment of persons infected with HTLV-III (AIDS) virus Patent #: 4888346 Issued on: 12/19/1989 Inventor: Bihari, et al. Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists Patent #: 4889860 Issued on: 12/26/1989 Inventor: Rzeszotarski, et al. N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans and derivatives Patent #: 4990617 Issued on: 02/05/1991 Inventor: Boswell, et al. Method of treating chronic fatigue syndrome using an opiate receptor antagonist Patent #: 5013739 Issued on: 05/07/1991 Inventor: Bihari, et al. InventorApplication No. 163930 filed on 12/08/1993 US Classes:514/282One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)Examiners Primary: Richter, Johann Assistant: Hydorn, Michael B.Attorney, Agent or FirmInternational Class A61K 031/485
AbstractThe specification discloses a method of treating a human or animal patient suffering from a pain syndrome secondary to nerve injury comprising daily administration to such patient of from about 0.4 milligrams to about 2.0 milligrams of the opiate-receptor antagonist naloxone for a treatment period of from around 3 months to around 12 months, depending upon the patient's needs. Delivery is preferably at or near the nerve injury site by a number of conventional injection methods. Other References- "A Randomized, Controlled Trail of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury", vol. 322, New Eng. J. Med., (May 1990), pp. 1405-1411, Bracken et al
- "Opiate-Receptor Antagonist Nalmefene Improves Neurological Recovery after Traumatic Spinal Cord Injury in Rates through a Central Mechanism", vol. 245, J. Pharmacology & Experimental Therapeutics, 742-48 (1988), Faden et al
- "111-Prostaglandin Hyperalgesia: Relevance of the Peripheral Effect for the Analgesic Action of Opioid-Antagonists", Prostaglandins, Aug. 1979, vol. 18, No. 2, pp. 201-208, Ferreira et al
- "Site of Analgesic Action of Aspirin-like Drugs and Opioids", In Mechanisms of Pain and Analgesic Compounds, New York: Raven Press pp. 309-321, Ferreira, 1979
- "Endogenous Opiates and Nociception: A Possible Functional Role in Both Pain Inhibition and Detection as Revealed by Intrathecal Naloxone", Neuroscience Letters, vol. 24 (1981) pp. 161-164, Dickenson et al
- "Effect of Naloxone Upon Diffuse Noxious Inhibitory Controls (DNIC) in the Rat", Brain Research vol. 240 (1981) 387-402, Le Bars et al
- "Reaction Thresholds to Pressure in Edematous Hindpaws of Rates and Responses to Analgesic Drugs", The Journal of Pharmacology and Experimental Therapeutics vol. 150, No. 1, pp. 165-171 Winter et al
- "Analgesia Produced by Low Doses of the Opiate Antagonist Naloxone in Arthritic Rats is Reduced in Morphine-Tolerant Animals", Brian Research, vol. 371 (1986), pp. 37-41 Kayser et al
- "Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain", Nature, vol. 278, (1979), pp. 740-741, Levine et al
- "Local Inhibition of Inflammatory Pain by Naloxone and its N-Methyl Quaternary Analogue," European Journal of Pharmacology, vol. 96, pp. 277-283, Rios et al., 1983
- "Analgesia and hyperalgesia produced in the rat by intrathecal naloxone", Brain Research, vol. 189 (1980), pp. 593-597, Woolf
- "Behavorial evidence for a bidirectional effect of systemic naloxone in a model of experimental neuropathy in the rat", Brain Research, vol. 494 (1989), pp. 276-384, Attal et al
- "Behavioural and electrophysiological studies on the paradoxial antinociceptive effects of an extremely low dose of naloxone in an animal model of acute and localized inflammation", Exp Brain Res (1988) pp. 402-410 Kayser et al
- "II-Prostaglandin Hyperalgesia: The Peripheral Analgesic Activity of Morphine, Enkephalins and Opioid Antagonists", Prostaglandins, vol. 18, pp. 191-200, Ferreira et al. 1979
- "I-Prostaglandin Hyperalgesia, A cAMP/CA2+ Dependent Process", Prostaglandins, vol. 18, No. 2 (1979), pp. 179-190, Ferreira et al
- "Drug Interaction in the Field of Analgesic Drugs", Proceedings of the Royal Society of Medicine, vol. 58, pp. 978-983, Lasagne, 1978
- "Naloxone alters pain perception and somatosensory evoked potentials in normal subjects", Nature, vol. 270 (1977), pp. 620-622, Buchsbaum et al
- "Antinociceptive Activity of Narcotic Agonist and Partial Agonist Analgesics and other Agents in the Tail-Immersion Test in Mice and Rats", Neuropharmacology, vol. 15 (1976), pp. 683-688, Sewell et al
- "Inhibition of Inflammatory Pain by Naloxone and its N Methyl Quaternary Analogue", Life Sciences, vol. 31 (1982), pp. 1209-1212, Rios et al
- "Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats", Brain Research, vol. 226 (1981) pp. 344-348, Kayser et al
- "Opioid and Nonopioid Mechanism May Contribute to Dynorphin's Pathophysiological Actions in Spinal Cord Injury", Annals of Neurology, vol. 27, No. 1 (1990), pp. 67-74, Faden
- "Dynorphin A-(1-17) Induces Alterations in Free Fatty Acids, Excitatory Amino Acids, and Motor Function Through An Opiate-Receptor-Mediated Mechanism", The Journal of Neuroscience (1990), 10(12), pp. 3793-3800, Bakshi et al
- "Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data", J. Neurosurg vol. 76 pp. 23-31 (1992), Bracken et a
|
|