Method and compositions for topical application to the skin for prevention and/or treatment of radiation-induced skin damage

Patent 5376361 Issued on December 27, 1994. Estimated Expiration Date:

January 13, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Cosmetic stick
Patent #: 4695452
Issued on: 09/22/1987
Inventor: Gannis , et al.

Method for the treatment of aging or photo-damaged skin
Patent #: 4938969
Issued on: 07/03/1990
Inventor: Schinitsky, et al.

Method of and composition for the prevention of solar radiation exposure-induced formation of carcinogenic skin lipid degradation products
Patent #: 4975272
Issued on: 12/04/1990
Inventor: Voyt

Cosmetic preparation incorporating stabilized ascorbic acid Patent #: 4983382
Issued on: 01/08/1991
Inventor: Wilmott, et al.

Inventor

Perricone, Nicholas V.

Application

No. 003603 filed on 01/13/1993

US Classes:

424/59, TOPICAL SUN OR RADIATION SCREENING, OR TANNING PREPARATIONS424/60, Aromatic acid or derivative containing (e.g., aminobenzoic acid or methyl salicylate, etc.)514/474Ascorbic acid or derivative (e.g., vitamin C, etc.)

Examiners

Primary: Ore, Dale R.

Attorney, Agent or Firm

St. Onge Steward Johnston & Reens

Foreign Patent References

291960 EP 11/12/1988
337464 EP 10/12/1989
2000507 DE 07/12/1970
52-61239 JP 05/12/1977
1152613 JP 07/12/1986
ZA75/6475 ZA 05/12/1976

International Classes

A61K 007/42
A61K 007/44
A61K 031/34

Abstract

A method for the prevention and/or treatment of radiation-induced skin damage, particularly ultraviolet-induced skin burn (e.g., sunburn), in which a tocotrienol, a derivative thereof or a vitamin E preparation enriched with tocotrienol or a tocotrienol derivative, is topically applied to the exposed or affected skin areas. A fat-soluble fatty acid ester of ascorbic acid such as palmityl ascorbate is preferably applied with the tocotrienol in association with a dermatologically acceptable carrier. Tocotrienol augments the efficacy of sunscreens containing compounds that reduce penetration of or absorb ultraviolet radiation.