Method of stabilizing aerosol formulations
Patent 5376359 Issued on December 27, 1994. Estimated Expiration Date: 
July 7, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 7, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProcess for the preparation of a mixture of an anti-inflammatory steroid and a fluoro-chloro-hydrocarbon to be used as a propellant Aerosol compositions containing finely divided solid materials Surface treating agent and the process therefor 5118494 Aerosol drug formulations Patent #: 5126123 InventorAssigneeApplicationNo. 909596 filed on 07/07/1992US Classes:424/46, Powder or dust containing424/45, Organic pressurized fluid424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)514/772.3, Solid synthetic organic polymer514/957, VAPOR EMMITTING COMPOSITION514/958, FOR SMOKING OR INHALING514/970CONTAINING DESIGNATED INGREDIENT TO STABILIZE AN ACTIVE INGREDIENTExaminersPrimary: Webman, Edward J.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 009/14A61K 047/30 AbstractA method of making a stabilized aerosol drug formulation is disclosed, along with the formulations so produced and metered drug inhalers containing the same. The method comprises combining a solid particulate drug composition with a fluoropolymer in a liquid fluorocarbon aerosol propellant to form a stable suspension. Further stabilization can be achieved by cooling the suspension for a time and to a temperature sufficient to adsorb the fluoropolymer to the solid particulate drug composition in the liquid fluorocarbon aerosol propellant. Preferred propellants for carrying out the invention are 1,1,1,2-tetrafluoroethane, heptafluoropropane, and mixtures thereof, and preferred fluoropolymers for carrying out the invention are fluoropolyethers.Other References
Field of SearchOrganic pressurized fluidPowder or dust containing Monomer contains oxygen Particulate form (e.g., powders, granules, beads, microcapsules, and pellets) VAPOR EMMITTING COMPOSITION FOR SMOKING OR INHALING CONTAINING DESIGNATED INGREDIENT TO STABILIZE AN ACTIVE INGREDIENT Solid synthetic organic polymer ASTHMA DIURETIC VASODILATOR | |
