U.S. patents available from 1976 to present.
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Preparation of omeprazole and lansoprazole

Patent 5374730 Issued on December 20, 1994. Estimated Expiration Date: Icon_subject November 4, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
Patent #: 4255431
Issued on: 03/10/1981
Inventor: Junggren ,   et al.

2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles Patent #: 4628098
Issued on: 12/09/1986
Inventor: Nohara ,   et al.

Inventors

Assignee

Application

No. 145572 filed on 11/04/1993

US Classes:

546/273.7Chalcogen bonded directly to a ring carbon of the 1,3-diazole ring

Examiners

Primary: Fan, Jane T.

Attorney, Agent or Firm

International Class

C07D 401/12

Abstract

Omeprazole and lansoprazole, which are chemically pyridine-benzimidazole sulfinyl compounds, are produced from the corresponding acetamide-sulfide compounds by a process of oxidation to form the amide sulfinyl compound, followed by alkaline hydrolysis to the sulfinyl carboxylate or salt, and decarboxylation.

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