U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Composition and method for transdermal delivery of diclofenac

Patent 5374661 Issued on December 20, 1994. Estimated Expiration Date: Icon_subject March 16, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3524916

3749773

Topical compositions
Patent #: 4009254
Issued on: 02/22/1977
Inventor: Renold

Topical steroid formulation in form of lotion or cream
Patent #: 4048310
Issued on: 09/13/1977
Inventor: Chen, et al.

Antiinflammatory analgesic gelled ointment
Patent #: 4309414
Issued on: 01/05/1982
Inventor: Inagi ,   et al.

Topical use of dyphylline and dyphylline containing compositions
Patent #: 4341783
Issued on: 07/27/1982
Inventor: Scheindlin

Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids, novel carboxylic acid salts and the production thereof
Patent #: 4407824
Issued on: 10/04/1983
Inventor: Eckert

Skin treatment compositions
Patent #: 4424234
Issued on: 01/03/1984
Inventor: Alderson ,   et al.

Resinate of a substituted carboxylic acid, the preparation and use thereof, and pharmaceutical compositions containing it
Patent #: 4510128
Issued on: 04/09/1985
Inventor: Khanna

Gel preparations for external application
Patent #: 4543251
Issued on: 09/24/1985
Inventor: Kamishita

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Inventor

Assignee

Application

No. 032724 filed on 03/16/1993

US Classes:

514/772.4, Polymer from ethylenic monomers only514/887, Topical Treatment514/944, GEL514/946PENETRANT OR ABSORBENT (ENHANCES PENETRATION INTO SUBJECT TREATED)

Examiners

Primary: Phelan, D. Gabrielle

Attorney, Agent or Firm

International Class

A01N 025/00

Abstract

The topical drug delivery composition and method of the present invention provides a composition and method for delivering amounts of diclofenac effective for treating inflamed and/or painful joints or muscles percutaneously via a gel. Diclofenac sodium is solubilized in a mixture of water, a low molecular weight alcohol, and a glycol. In the present invention, the transdermal flux of diclofenac is unexpectedly enhanced by the addition of an ether alcohol and a fatty alcohol ester. The transdermal flux can be further enhanced by the addition of a glycol such as hexylene glycol.

Other References

  • Kyuki et al., "Anti-Inflammatory Effect of Diclofenac-Sodium Ointment (Cream) in Topical Application", Japan J. Pharmacol., vol. 33, pp. 121-132 (1983)
  • Nishihata et al., "Percutaneous Absorption of Diclofenac in Rats and Humans: Aqueous Gel Formulation", Int. J. Pharm., vol. 46, pp. 1-7 (1988
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