Imidazole dermal penetration enhancers
December 20, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesClotrimazole-betamethasone dipropionate combination Antimycotic agent, in the form of sticks, with a high release of active compound Substituted tert.-butanol derivatives and antimycotic agents containing these compounds Antimycotic agents L--amino acids as transdermal penetration enhancers Steroid lotion Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols Substituted hydroxyalkyl-azoles and their use as antimycotics Antifungal dermatological solution Patent #: 4912124 InventorApplicationNo. 771590 filed on 10/04/1991US Classes:514/171, With additional active ingredient514/161, With heterocyclic compound514/192, 1-thia-4-aza-bicyclo (3.2.0) heptane ring containing (including dehydrogenated) (e.g., penicillins, etc.)514/200, 1-thia-5-aza-bicyclo (4.2.0) octane ring containing (including dehydrogenated) (e.g., cephalosporins, etc.)514/254.07, Chalcogen hetero ring attached directly or indirectly to the piperazine ring by nonionic bonding514/947Topical applicationExaminersPrimary: Hollinden, Gary E.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/495A61K 031/50 AbstractTopically administerable compositions are described which contain, in a pharmaceutically acceptable vehicle, a combination of a drug whose dermal penetration can be enhanced and a combination of substances, which combination enhances and controls the penetration of the compositions through the skin. The combination contains an antifungal amount of an imidazole and a certain amount of either propylene glycol, specified fatty acid ester(s) or a mixture of propylene glycol and specified fatty acid ester(s).Other References
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