Preparation for transdermal drug administration

Patent 5368860 Issued on November 29, 1994. Estimated Expiration Date:

November 29, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Bandage for sustained delivery of drugs
Patent #: 4655768
Issued on: 04/07/1987
Inventor: Marecki , et al.

Color-matched sterile adhesive bandages containing melanin-like pigment composition Patent #: 5120325
Issued on: 06/09/1992
Inventor: Dow, Jr.

Inventors

Assignee

Nitto Denko Corporation

Application

No. 798149 filed on 11/26/1991

US Classes:

424/448, Pressure sensitive adhesive means424/443, Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicaments424/449Transdermal or percutaneous

Examiners

Primary: Page, Thurman K.
Assistant: Horne, Leon R.

Attorney, Agent or Firm

Sughrue, Mion, Zinn, Macpeak & Seas

Foreign Patent References

0156080 EP. 10/13/1985
0331392 EP. 09/13/1989
WO8911872 EP. 12/13/1989
0393727 EP. 10/13/1990

International Class

A61F 013/02

Foreign Application Priority Data

1990-11-30 JP

Abstract

A preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in a proportion of 40-65 weight %. Since the ratio of the amount of the undissolved local anesthetic (Ac) to that of the dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration of the present invention is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.